Guidance A STRATEGY FOR TESTING OF CHEMICALS FOR GENOTOXICITY Five guidance statements on testing chemicals with no or inadequate genotoxicity data. Get emails about this page DOCUMENTS

GUIDANCE ON A STRATEGY FOR GENOTOXICITY TESTING OF CHEMICALS Ref: Ref COM/G strategy – Version 4.0 (2021) PDF, 562 KB, 74 pages This file may not be suitable for users of assistive

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[email protected]. Please tell us what format you need. It will help us if you say what assistive technology you use. GUIDANCE ON A STRATEGY FOR GENOTOXICITY TESTING OF CHEMICAL SUBSTANCES:

help us if you say what assistive technology you use. GUIDANCE ON A STRATEGY FOR GENOTOXICITY TESTING OF CHEMICAL SUBSTANCES: IN VITRO ASSESSMENT Ref: Ref COM/G1 – Version 2.0 (2021) PDF,

382 KB, 38 pages This file may not be suitable for users of assistive technology. Request an accessible format. If you use assistive technology (such as a screen reader) and need a version

of this document in a more accessible format, please email [email protected]. Please tell us what format you need. It will help us if you say what assistive technology you use. GUIDANCE ON A

STRATEGY FOR GENOTOXICITY TESTING OF CHEMICAL SUBSTANCES: IN VIVO TESTING Ref: Ref COM/G2 – Version 2.0 (2021) PDF, 325 KB, 32 pages This file may not be suitable for users of assistive

technology. Request an accessible format. If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email

[email protected]. Please tell us what format you need. It will help us if you say what assistive technology you use. GUIDANCE ON MUTAGENIC HAZARD ASSESSMENT AND A STRATEGY FOR GENOTOXICITY

TESTING OF CHEMICALS WITH INADEQUATE GENOTOXICITY DATA PDF, 67.8 KB, 10 pages This file may not be suitable for users of assistive technology. Request an accessible format. If you use

assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email [email protected]. Please tell us what format you need. It will help

us if you say what assistive technology you use. DETAILS These statements set out the recommendations of the Committee on Mutagenicity of Chemicals in Food, Consumer Products and the

Environment (COM). They include: * a 3-stage strategy for testing chemicals with no existing genotoxicity data * recommendations for stage 0: prescreening considerations prior to testing *

recommendations for stage 1: a strategy for in vitro assessment * recommendations for stage 2: a strategy for in vivo testing * a final stage of recommendations for chemicals with inadequate

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