<i> Squires is a Washington Post writer. </i> Give up cigarette smoking and the body craves sweet-tasting food. Evidence suggests that nicotine acts through two separate

metabolic regulating systems in the body: Nicotine lowers the level of the hormone insulin, which controls blood sugar. When nicotine is stopped, insulin levels rise. Some believe that the

craving for sweets among ex-smokers may be triggered by this insulin-nicotine connection. Nicotine may also alter levels of serotonin, a substance that helps regulate mood. When serotonin

levels plummet, so does mood. Raise serotonin and a person feels less depressed. Researchers now want to learn how nicotine may affect the craving for carbohydrates. Cigarette smoking is

that most smokers gain after giving up the habit? And why do certain situations more than others seem to condition people to crave a cigarette? The answers to these and other questions about

addiction are emerging from several laboratories throughout the country. At the University of Pittsburgh, for example, Dr. Saul Shiffman, a clinical psychologist, studies “chippers”--people

who are able to smoke just a few cigarettes regularly but never become pack-a-day smokers. Shiffman, who presented his findings recently at the American Psychological Assn. annual meeting

in New York, estimates that about 4% to 5% of the 55 million Americans who smoke are chippers. Unlike the pack-a-day smoker, chippers smoke no more than five cigarettes a day and usually

smoke only about four days a week. Chippers are not smokers who have tried to quit and slipped back to their old habits but are people who can be satisfied smoking just a few cigarettes on a

regular basis. Rather than smoking because they feel pressured, tense or are experiencing withdrawal from nicotine, chippers usually smoke because they are happy or are enjoying themselves,

for instance at a party. The fact that some smokers can remain chippers baffles researchers on smoking. “We know how addicting tobacco is,” Shiffman said. “These people shouldn’t exist

according to the theory (of smoking and nicotine), and yet they do. It’s very weird.” New research on chippers and heavy smokers is helping to clear up part of the mystery. For example, in a

study of 18 chippers and 29 smokers, Shiffman found that chippers are far less likely to experience the strong withdrawal symptoms that heavy smokers feel when they go without a cigarette.

In the study, both groups had to abstain from cigarettes overnight before coming into the laboratory for testing. “Chippers came in calm and stayed calm (after not smoking overnight),”

Shiffman said. “Smokers came in pretty uncomfortable. They were upset. They smoked a cigarette and then they got calm.” Chippers were also less likely than heavy smokers to have relatives

who smoked. If a chipper’s family member smoked, the odds were, Shiffman said, that the relative had successfully given up smoking. Heavy smokers and chippers also differed on early smoking

experience. Contrary to what Shiffman expected, chippers described their first cigarette as a fairly uneventful experience. “They reported experiencing fewer (bad) symptoms (of smoking) the

first time they tried a cigarette than heavy smokers did,” he said. By comparison, heavy smokers reported that their first cigarette was an unpleasant experience, marked by such symptoms as

nausea, headache, dizziness and coughing. “These findings surprised me,” Shiffman said. But the results are consistent with a study from Britain that found that nonsmokers who tried

cigarettes as adolescents reported feeling the least number of unpleasant symptoms when compared to both chippers and heavy smokers. Defining the biological factors that seem to prevent

chippers from becoming heavy smokers is a key goal of smoking research. “If we could understand what it is that protects chippers from addiction, that might give us a big clue about what

causes dependence in the first place and maybe how we could protect others,” Shiffman said. Finding the answer to cigarette chippers, Shiffman said, would be the equivalent of finding

someone who is immune to a virus. “It might give us a big clue about what causes addiction in the first place, and how to prevent it,” he said. Additional clues to biological dynamics of

addiction are also emerging from studies of how nicotine exerts its effects on the body. At the Uniformed Services University of Health Sciences in Bethesda, Dr. Neil Grunberg, a health

psychologist and addiction researcher, has found that nicotine alters the desire for sweet-tasting food and for carbohydrates. Give up cigarette smoking, and the body craves sweet-tasting

food. Evidence from animal studies suggests that nicotine acts through two separate metabolic regulating systems in the body. To affect the desire for sweet-tasting food, Grunberg said,

nicotine seems to alter levels of the hormone insulin. (Insulin controls blood levels of the sugar glucose. As insulin levels rise, glucose is stored in cells throughout the body. When

insulin levels drop, the cells release glucose into the blood for energy.) Nicotine tends to lower insulin levels. Studies also show that when nicotine is stopped, insulin levels rise,

leading Grunberg and his colleagues to propose that the craving for sweets among recent ex-smokers may be triggered by this insulin-nicotine connection. To affect the craving for

carbohydrates or starchy foods, Grunberg believes, nicotine may alter levels of serotonin, a substance that helps regulate mood. When serotonin levels plummet, so does mood. Raise serotonin

and a person feels better--less depressed. To test how nicotine may affect serotonin levels, Grunberg and his colleagues are embarking on additional studies. Since serotonin and insulin

pathways in the body are closely tied to appetite, Grunberg believes that nicotine, and perhaps other addictive drugs, “may actually affect similar systems in the body as food does.” “Think

about it,” Grunberg said. “When people feel hungry, they will search for food in much the same way that a smoker who just smoked the last cigarette in a pack will search for a cigarette.”

Just as serotonin and nicotine blood levels seem to change for a smoker, they also are altered for the person who is hungry. But once a hungry individual finds food--just as once the smoker

can light up again--the craving to eat goes away and insulin and serotonin levels return to normal. By tapping into the body’s system that controls hunger, Grunberg thinks that it may be

possible to explain why nicotine--and perhaps other addictive drugs as well--are able to exert a such powerful hold on the body. And although this theory still needs more research, Grunberg

said that many alcohol and drug abuse programs already recognize the changes in appetite that often strike people attempting to kick their habits and advise their participants to eat sweet

foods--doughnuts, cookies and candy--to help soften the craving for another drink or a fix. In addition to biological factors, the setting where alcoholics, smokers and drug abusers engage

in their habits may also play an important role in addiction. At the National Institute of Drug Abuse Addiction Research Center in Baltimore, Dr. Jack Henningfield studies cocaine addicts in

the laboratory. In this experimental setting, the addicts are allowed to give themselves cocaine, but to do so, they have an intravenous tube placed in their arms and must press an

elaborate series of switches and buttons in the same pattern to have the drug administered. Henningfield has found that the addicts give themselves a regular and constant dose. MORE TO READ