ABSTRACT OBJECTIVE: To examine the association of components of the metabolic syndrome with lower urinary tract symptoms (LUTS), which often result from prostate enlargement and heightened

tone of prostate and bladder smooth muscle. DESIGN: Third National Health and Examination Survey (NHANES III), from which LUTS cases and controls were selected. SUBJECTS: A total of 2372 men

aged 60+ y who participated in NHANES III. LUTS cases were men with at least three of these four symptoms: nocturia, incomplete bladder emptying, weak stream, and hesitancy, and who never

had noncancer prostate surgery. Controls were men without any of the symptoms and who never had noncancer prostate surgery. MEASUREMENTS: As part of NHANES III, an oral glucose tolerance

1.20–2.59) appeared to be positively associated with LUTS. The odds of LUTS increased with increasing glycosylated hemoglobin (_P_-trend=0.005). No statistically significant associations

between fasting or 2-h glucose or fasting insulin and LUTS were observed. However, men classified as having three or more components of the metabolic syndrome had an increased odds of LUTS

(OR=1.80; 95% CI 1.11–2.94). CONCLUSION: These findings support the role for metabolic perturbations in the etiology of LUTS. Access through your institution Buy or subscribe This is a

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METABOLIC HEALTH, AND UROLOGICAL DISORDERS IN ADULTS: A NATIONWIDE POPULATION-BASED STUDY Article Open access 22 April 2021 A COMMUNITY-BASED STUDY ON LOWER URINARY TRACT SYMPTOMS IN

MALAYSIAN MALES AGED 40 YEARS AND ABOVE Article Open access 11 February 2022 THE IMPACT OF SMOKING ON MALE LOWER URINARY TRACT SYMPTOMS (LUTS) Article Open access 19 November 2020 REFERENCES

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supported by the Fund for Research and Progress in Urology, Johns Hopkins Medical Institutions. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Epidemiology, Johns Hopkins

Bloomberg School of Public Health, Baltimore, MD, USA S Rohrmann & E A Platz * Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo,

NY, USA E Smit * Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA E Giovannucci * Department of Nutrition, Harvard

School of Public Health, Boston, MA, USA E Giovannucci * Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA E Giovannucci * The James Buchanan Brady Urological

Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA E A Platz Authors * S Rohrmann View author publications You can also search for this author inPubMed Google Scholar * E Smit

View author publications You can also search for this author inPubMed Google Scholar * E Giovannucci View author publications You can also search for this author inPubMed Google Scholar * E

A Platz View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to E A Platz. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rohrmann, S., Smit, E., Giovannucci, E. _et al._ Association between markers of the metabolic syndrome and lower urinary tract symptoms in

the Third National Health and Nutrition Examination Survey (NHANES III). _Int J Obes_ 29, 310–316 (2005). https://doi.org/10.1038/sj.ijo.0802881 Download citation * Received: 09 February

2004 * Revised: 07 July 2004 * Accepted: 10 July 2004 * Published: 11 January 2005 * Issue Date: 01 March 2005 * DOI: https://doi.org/10.1038/sj.ijo.0802881 SHARE THIS ARTICLE Anyone you

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Springer Nature SharedIt content-sharing initiative KEYWORDS * NHANES III * lower urinary tract symptoms * metabolic syndrome * glycosylated hemoglobin * elderly men