ABSTRACT BACKGROUND: People with obesity and/or the metabolic syndrome have an increased risk for developing diabetes and cardiovascular disease and may have low adiponectin levels. The

obesity associated with Prader–Willi syndrome (PWS) would be expected to have similar complications. However, it was recently reported that, despite their adiposity, people with PWS have

reduced visceral fat and are less likely to develop diabetes mellitus or the metabolic syndrome compared with people with simple obesity. OBJECTIVE: To determine if plasma adiponectin levels

and other variables relevant to diabetes and cardiovascular risk are different in a cohort of PWS subjects with known genetic subtypes compared with age-, sex- and weight-matched control

levels were significantly higher in PWS (15.5±8.2 _μ_g/ml) than in obese controls (7.5±2.7 _μ_g/ml). A significant positive correlation was found with insulin sensitivity in PWS subjects

(_r_=0.75, _P_=0.0003) but not in obese controls (_r_=0.36, _P_=0.20). DISCUSSION: Our study confirmed an earlier observation of higher adiponectin levels in PWS subjects and less insulin

resistance proportionate to their obesity status than found in subjects with simple obesity. Furthermore, no differences were seen in PWS subjects with the chromosome 15 deletion or maternal

disomy 15. The reported excessive visceral adiposity in subjects with simple obesity compared with PWS may be associated with decreased production and lower circulating levels of

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Article  Google Scholar  Download references ACKNOWLEDGEMENTS We thank Brian Sheridan at the Regional Biochemistry Laboratory, Royal Victoria Hospital, Belfast, Northern Ireland, for

measuring plasma insulin and C-peptide and Karen Brezner for her assistance in processing the plasma samples. Support was provided by Grant PO1HD30329 and RO1HD41672 from the National

Institutes of Health; Children's Mercy Hospitals Physician Scientist Award (01.4871); and the Hall Family Foundation (01.3905) to MGB as well as Grant DK37373 from the National

Institutes of Health to SPK. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine, Division of Endocrinology, University of Florida, Gainesville, FL, USA L Kennedy *

Children's Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA D C Bittel, N Kibiryeva & M G Butler * Department of

Neuroscience, University of Florida, Gainesville, FL, USA S P Kalra & R Torto Authors * L Kennedy View author publications You can also search for this author inPubMed Google Scholar * D

C Bittel View author publications You can also search for this author inPubMed Google Scholar * N Kibiryeva View author publications You can also search for this author inPubMed Google

Scholar * S P Kalra View author publications You can also search for this author inPubMed Google Scholar * R Torto View author publications You can also search for this author inPubMed 

Google Scholar * M G Butler View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to M G Butler. RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kennedy, L., Bittel, D., Kibiryeva, N. _et al._ Circulating adiponectin levels, body composition and obesity-related variables

in Prader–Willi syndrome: comparison with obese subjects. _Int J Obes_ 30, 382–387 (2006). https://doi.org/10.1038/sj.ijo.0803115 Download citation * Received: 05 February 2005 * Revised: 25

May 2005 * Accepted: 28 July 2005 * Published: 04 October 2005 * Issue Date: 01 February 2006 * DOI: https://doi.org/10.1038/sj.ijo.0803115 SHARE THIS ARTICLE Anyone you share the following

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SharedIt content-sharing initiative KEYWORDS * adiponectin * simple obesity * Prader–Willi syndrome (PWS) * body composition * obesity-related variables * insulin resistance and sensitivity