ABSTRACT OBJECTIVE: To test for association of the ectonucleotide pyrophosphatase/phosphodiesterase 1 (_ENPP1_) K121Q polymorphism with body mass index (BMI) and diabetes in a large sample

of Caucasians and African-Americans by selectively genotyping individuals at the extremes of the phenotypic distribution. SUBJECTS: Subsets comprising the extremes of the BMI distribution

(10th–20th and above the 90th BMI percentile for Caucasians and between the 10th–30th and above the 80th percentile for African-Americans) from a group of 10 260 Caucasian and 2268

African-American adults participating in New York Cancer Project were studied. METHODS: Subjects were genotyped for the _ENPP1_ K121Q polymorphism by pyrosequencing and tested for

effects of age, gender or race. By logistic regression analysis, the K121Q alleles had no significant effect on diabetes status (_P_=0.37) in obese subjects. CONCLUSION: In both Caucasians

and African-Americans, the K121 polymorphism in _ENPP1_ was associated with increased BMI, but not with diabetes. Access through your institution Buy or subscribe This is a preview of

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ACKNOWLEDGEMENTS This study was supported by grants NIDDK 52431 and 56336, an American Diabetes Association mentored fellowship and support provided by the Academic Medicine Development

Corporation (AMDeC) of New York. Naoki Matsuoka is also supported by Uehara Memorial Foundation and Foundation for Growth Science, Tokyo, Japan. We thank Robert Lundsten, Frank Fries, and

Rebecca Yohannes for technical assistance and Ana Ignat, Lizzett Santiago, and Richard Sarver for assistance with manuscript preparation. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA N Matsuoka, R L Leibel & W K Chung * Department of

Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA A Patki, H K Tiwari & D B Allison * Department of Pathology, University of Alabama at Birmingham, Birmingham, AL,

USA H K Tiwari * Department of Public Health & Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL, USA D B Allison * Department of Biomedical

Informatics, College of Physicians and Surgeons, Columbia University, New York, NY, USA S B Johnson * The Robert S Boas Center for Genomics and Human Genetics, The North Shore-Long Island

Jewish Research Institute, Manhasset, NY, USA P K Gregersen * Department of Medicine, Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA

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CITE THIS ARTICLE Matsuoka, N., Patki, A., Tiwari, H. _et al._ Association of K121Q polymorphism in _ENPP1_ (_PC-1_) with BMI in Caucasian and African-American adults. _Int J Obes_ 30,

233–237 (2006). https://doi.org/10.1038/sj.ijo.0803132 Download citation * Received: 13 April 2005 * Accepted: 03 July 2005 * Published: 11 October 2005 * Issue Date: 01 February 2006 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * _ENPP1_ * K121Q * BMI * association * Caucasian *

African-American