ABSTRACT Variation in telomerase activity is correlated with cellular senescence and tumour progression. However, although the enzymatic activity of telomerase has been well studied, very

little is known about how expression of telomerase genes is regulated in mammalian cells. We have therefore cloned the promoter regions of the human (hTR), and mouse, (_TERC_), telomerase

RNA genes in order to identify the regulatory elements controlling telomerase RNA gene transcription. 1.76 kb encompassing the hTR gene promoter region was sequenced, as was 4 kb

encompassing the _TERC_ promoter. No significant sequence similarity could be detected in comparisons between human and mouse 5′-regions, flanking the transcribed sequences. However, both

gene constructs in Swiss3T3 and A9 cells identified the elements responsible for promoter activity are contained in a 73 bp region upstream of the transcriptional start site. These studies

have implications for novel transcription targeted cancer therapies. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MODIFICATION OF THE TELOMERASE GENE WITH HUMAN REGULATORY SEQUENCES RESETS

MOUSE TELOMERES TO HUMAN LENGTH Article Open access 04 February 2025 TERT PROMOTER ALTERATIONS COULD PROVIDE A SOLUTION FOR PETO’S PARADOX IN RODENTS Article Open access 30 November 2020

TELOMERES REFORGED WITH NON-TELOMERIC SEQUENCES IN MOUSE EMBRYONIC STEM CELLS Article Open access 17 February 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * CRC Department of Medical

Oncology, University of Glasgow, CRC Beatson Laboratories, Alexander Stone Building, Garscube Estate, Switchback Road, Bearsden, G61 1BD, Glasgow Jiang-Qin Zhao, Stacey F Hoare, Sharon Muir 

& W Nicol Keith * Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, G61 1BD, Glasgow, UK Robert McFarlane, E Kenneth Parkinson & 

Donald M Black Authors * Jiang-Qin Zhao View author publications You can also search for this author inPubMed Google Scholar * Stacey F Hoare View author publications You can also search for

this author inPubMed Google Scholar * Robert McFarlane View author publications You can also search for this author inPubMed Google Scholar * Sharon Muir View author publications You can

also search for this author inPubMed Google Scholar * E Kenneth Parkinson View author publications You can also search for this author inPubMed Google Scholar * Donald M Black View author

publications You can also search for this author inPubMed Google Scholar * W Nicol Keith View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zhao, JQ., Hoare, S., McFarlane, R. _et al._ Cloning and characterization of human and mouse telomerase RNA gene

promoter sequences. _Oncogene_ 16, 1345–1350 (1998). https://doi.org/10.1038/sj.onc.1201892 Download citation * Received: 17 December 1997 * Revised: 03 February 1998 * Accepted: 05 February

1998 * Published: 19 March 1998 * Issue Date: 12 March 1998 * DOI: https://doi.org/10.1038/sj.onc.1201892 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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KEYWORDS * telomerase * gene expression * hTR * _terc_ * gene promoter * gene transcription