ABSTRACT Non small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the United States and worldwide. Unfortunately, standard therapies remain inadequate. An increased

understanding of the molecular biology of lung cancer biology is required to develop more effective new therapies. In this report, we show that the Wnt pathway is activated through

Dishevelled (Dvl) overexpression in NSCLC. Analysis of freshly resected tumors and lung cancer cell lines demonstrate that Dvl-3, a critical mediator of Wnt signaling, is overexpressed.

Specifically, Dvl-3 was overexpressed significantly in 75% of fresh NSCLC microdissected samples compared to control paired matched normal lung samples. To evaluate the biological

_β_-catenin expression, resulting in reduction of Tcf-dependent transcriptional activity, and, importantly, growth inhibition. Taken together, these data support the novel hypothesis that

Dvl overexpression is critical to Wnt signaling activation and cell growth in NSCLC. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS AJUBA PROMOTES THE PROLIFERATION, INVASION AND MIGRATION OF NSCLC

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28 August 2024 BUB1 INDUCES AKT/MTOR PATHWAY ACTIVITY TO PROMOTE EMT INDUCTION IN HUMAN SMALL CELL LUNG CANCER Article Open access 04 September 2024 REFERENCES * Brantjes H, Barker N, van Es

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AUTHORS AND AFFILIATIONS * Thoracic Oncology Laboratory, UCSF Cancer Center, University of California at San Francisco, San Francisco, 94115, CA, USA Kazutsugu Uematsu, Biao He, Liang You, 

Zhidong Xu, Frank McCormick & David Mark Jablons * The Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, 113-8602, Japan Kazutsugu Uematsu Authors * Kazutsugu Uematsu

View author publications You can also search for this author inPubMed Google Scholar * Biao He View author publications You can also search for this author inPubMed Google Scholar * Liang

You View author publications You can also search for this author inPubMed Google Scholar * Zhidong Xu View author publications You can also search for this author inPubMed Google Scholar *

Frank McCormick View author publications You can also search for this author inPubMed Google Scholar * David Mark Jablons View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to David Mark Jablons. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Uematsu, K., He, B.,

You, L. _et al._ Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. _Oncogene_ 22, 7218–7221 (2003). https://doi.org/10.1038/sj.onc.1206817

Download citation * Received: 04 April 2003 * Revised: 08 May 2003 * Accepted: 15 May 2003 * Published: 16 October 2003 * Issue Date: 16 October 2003 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Dishevelled (Dvl) * Wnt signaling * non small cell lung

cancer * siRNA