ABSTRACT The paradigm of genetic alterations being restricted to direct DNA damage after exposure to ionizing radiation has been challenged by observations in which cells that are not

exposed to ionizing radiation exhibit responses typically associated with direct radiation exposure. These effects are demonstrated in cells that are the descendants of irradiated cells

(radiation-induced genomic instability) or in cells that are in contact with irradiated cells or receive certain signals from irradiated cells (radiation-induced bystander effects). There is

accumulating evidence that radiation-induced genomic instability may be a consequence of, and in some cell systems may also produce, bystander interactions involving intercellular

of inflammatory-type responses to radiation-induced stress and injury and contribute to the variety of pathological consequences of radiation exposures. Access through your institution Buy

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OTHERS IONIZING RADIATION RESULTS IN A MIXTURE OF CELLULAR OUTCOMES INCLUDING MITOTIC CATASTROPHE, SENESCENCE, METHUOSIS, AND IRON-DEPENDENT CELL DEATH Article Open access 23 November 2020

CHARACTERIZING THE ROLE OF PHLDA3 IN THE DEVELOPMENT OF ACUTE TOXICITY AND MALIGNANT TRANSFORMATION OF HEMATOPOIETIC CELLS INDUCED BY TOTAL-BODY IRRADIATION IN MICE Article Open access 09

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Research Council, The Leukaemia Research Fund and the Department of Health. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Molecular and Cellular Pathology, University of

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THIS ARTICLE Lorimore, S., Coates, P. & Wright, E. Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation.

_Oncogene_ 22, 7058–7069 (2003). https://doi.org/10.1038/sj.onc.1207044 Download citation * Published: 13 October 2003 * Issue Date: 13 October 2003 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * radiation * genetic instability * bystander effects *

clastogenic factors * inflammation