ABSTRACT A variety of factors cooperate to regulate neovessel formation and persistence. Proangiogenic growth factors have remained an area of intense interest due to their capacity to

promote endothelial cell (EC) proliferation and to initiate the angiogenic program. These growth factors are associated with increased cell survival, yet paradoxically, angiogenic ECs are

more susceptible to apoptosis than quiescent ECs. Survival is regulated by cooperation between growth factor receptors and integrins, which are in turn governed by the composition of the

local extracellular matrix (ECM). Integrin-mediated signaling is altered or disrupted by the presence of soluble, rather than matrix-bound ligands, thus providing a means by which ECM

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS INTEGRIN Α3Β1 PROMOTES VESSEL FORMATION OF GLIOBLASTOMA-ASSOCIATED ENDOTHELIAL CELLS THROUGH CALCIUM-MEDIATED MACROPINOCYTOSIS

AND LYSOSOMAL EXOCYTOSIS Article Open access 25 July 2022 NRP1 INTERACTS WITH ENDOGLIN AND VEGFR2 TO MODULATE VEGF SIGNALING AND ENDOTHELIAL CELL SPROUTING Article Open access 19 January

2024 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING IN HEALTH AND DISEASE: FROM MOLECULAR MECHANISMS TO THERAPEUTIC PERSPECTIVES Article Open access 19 May 2025 REFERENCES * Abramovitch R,

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AFFILIATIONS * Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road., La Jolla, 92037, CA, USA Dwayne G Stupack & David A Cheresh Authors * Dwayne G

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from the extracellular matrix: regulators of angiogenesis. _Oncogene_ 22, 9022–9029 (2003). https://doi.org/10.1038/sj.onc.1207110 Download citation * Published: 08 December 2003 * Issue

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endothelial cell * extracellular matrix * integrin