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ABSTRACT A role for the p52 NF-_κ_B subunit in tumorigenesis has been steadily emerging since its discovery as a gene associated with chromosomal translocations in B- and T-cell lymphomas.
Now Eliopoulos and co-workers have extended these studies to examine the effect of the Epstein–Barr virus (EBV)-encoded latent infection membrane protein 1 (LMP1) on p52. They find that LMP1
stimulates the processing of p100 to p52 NF-_κ_B. Moreover, nuclear p52 is also associated with LMP1 expression in tumor tissue biopsies. They also demonstrate that the pathway leading to
p100/p52 processing is distinct from that engaged by LMP1 to activate other NF-_κ_B subunits through I_κ_B_α_ degradation. A clearer picture is now developing of the important role that p52
NF-_κ_B plays during normal cell growth and how subverting its function can contribute to oncogenesis. Access through your institution Buy or subscribe This is a preview of subscription
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21, 8428–8436. * Xiao GT, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, Waterfield M and Sun SC . (2001). _EMBO J._, 20, 6805–6815. Download references ACKNOWLEDGEMENTS NDP is the recipient of a
Royal Society University Research Fellowship. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Gene Regulation and Expression, School of Life Sciences, MSI/WTB Complex, Dow Street,
University of Dundee, Dundee, DD1 5EH, UK Neil D Perkins Authors * Neil D Perkins View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR
Correspondence to Neil D Perkins. ADDITIONAL INFORMATION Commentary article on Eliopoulos _et al._ ‘Epstein–Barr virus-encoded latent infection membrane protein 1 (LMP1) regulates the
processing of p100 NF-_κ_B to p52 via an IKK_γ_/NEMO-independent signaling pathway’ RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Perkins, N.
Oncogenes, tumor suppressors and p52 NF-_κ_B. _Oncogene_ 22, 7553–7556 (2003). https://doi.org/10.1038/sj.onc.1207139 Download citation * Published: 23 October 2003 * Issue Date: 23 October
2003 * DOI: https://doi.org/10.1038/sj.onc.1207139 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link
is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * NF-_κ_B2 * Lyt-10 * NIK * IKK * P53 * Cyclin D1