ABSTRACT MUC1 is a transmembrane mucin that was initially cloned from malignant mammary epithelial cells as a tumor antigen. More than 90% of human breast carcinomas overexpress MUC1.

Numerous studies have demonstrated an interaction between MUC1 and other oncogenic proteins such as _β_-catenin, erbB receptors and c-Src, but a functional role for MUC1 in transformation

has not been identified. We previously reported the development of transgenic mice that overexpress human MUC1 in the mouse mammary gland (MMTV-MUC1). Analysis of these transgenic mice at an

early age demonstrated the ability of MUC1 to potentiate EGF-dependent activation of MAP kinase signaling pathways in the lactating mammary gland. We now report that multiparous MMTV-MUC1

undergo postlactational involution. Furthermore, uniparous MMTV-MUC1 transgenic mice display decreased postlactational apoptosis, elevated whey acidic protein expression and aberrant pErk2

activation. These findings are the first to determine that MUC1 overexpression promotes _in vivo_ transformation of the mammary gland. Access through your institution Buy or subscribe This

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LINEAGE PLASTICITY OF HER2 POSITIVE MAMMARY TUMORS Article 23 April 2022 STAT5 CONFERS LACTOGENIC PROPERTIES IN BREAST TUMORIGENESIS AND RESTRICTS METASTATIC POTENTIAL Article 19 October

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Lossnitzer A, Mooi WJ and Hilgers J . (1988). _Cancer Rev._, 11–12, 55–101. Download references ACKNOWLEDGEMENTS We are grateful to Dr J Taylor-Papadimitriou for the HMFG-2 antibody and

Biomira Inc. for the B27.29 antibody. We thank Dr Robert Cardiff and Dr Thomas Lidner for pathological analysis. We also thank Suresh Savarirayan and the animal care attendants for excellent

animal care, Marvin H Ruona for computer graphics and Carol Williams for assistance with manuscript. This work was supported by NIH RO1CA64389 (SJG), NIH F32CA81703 (JAS), DOD Breast Cancer

Research Program DAMD17-02-1-0476 (AAM) and Mayo Clinic College of Medicine. AUTHOR INFORMATION Author notes * Joyce A Schroeder Present address: Department of Molecular and Cellular

Biology, University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA * Melissa C Adriance Present address: Lawrence Berkeley National Lab, Cell and Molecular Biology, 1 Cyclotron

Road, MS 83-101, Berkeley, CA 94720, USA * Joyce A Schroeder and Azzah Al Masri: These authors contributed equally to this work AUTHORS AND AFFILIATIONS * Department of Biochemistry and

Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Scottsdale, Scottsdale, 85259, AZ, USA Joyce A Schroeder, Azzah Al Masri, Jennifer C Tessier, Kari L Kotlarczyk, Melissa C

Thompson & Sandra J Gendler * Tumor Biology Program, Mayo Clinic College of Medicine, Mayo Clinic Scottsdale, Scottsdale, 85259, AZ, USA Melissa C Adriance & Sandra J Gendler Authors

* Joyce A Schroeder View author publications You can also search for this author inPubMed Google Scholar * Azzah Al Masri View author publications You can also search for this author

inPubMed Google Scholar * Melissa C Adriance View author publications You can also search for this author inPubMed Google Scholar * Jennifer C Tessier View author publications You can also

search for this author inPubMed Google Scholar * Kari L Kotlarczyk View author publications You can also search for this author inPubMed Google Scholar * Melissa C Thompson View author

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AUTHOR Correspondence to Sandra J Gendler. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Schroeder, J., Masri, A., Adriance, M. _et al._ MUC1

overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation. _Oncogene_ 23, 5739–5747 (2004). https://doi.org/10.1038/sj.onc.1207713 Download citation *

Received: 09 January 2004 * Revised: 03 March 2004 * Accepted: 03 March 2004 * Published: 28 June 2004 * Issue Date: 29 July 2004 * DOI: https://doi.org/10.1038/sj.onc.1207713 SHARE THIS

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * mucin * involution * apoptosis * breast cancer * mammary gland