ABSTRACT Core binding factors are heterodimeric transcription factors containing a DNA binding Runx1, Runx2, or Runx3 subunit, along with a non DNA binding CBF_β_ subunit. All four subunits

are required at one or more stages of hematopoiesis. This review describes the role of Runx1 and CBF_β_ in the initiation of hematopoiesis in the embryo, and in the emergence of

hematopoietic stem cells. We also discuss the later stages of hematopoiesis for which members of the core binding factor family are required, as well as the recently described roles for

these proteins in autoimmunity. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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COACTIVATOR 3 (_SRC-3_/_AIB1_) IS ENRICHED AND FUNCTIONAL IN MOUSE AND HUMAN TREGS Article Open access 09 February 2021 BIOMOLECULAR CONDENSATES IN IMMUNE CELL FATE Article 28 January 2025

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Zhao FQ, Sheng ZM, Tsai MM, Hubbs AE, Wang R, O’Leary TJ, Izon DJ and Taubenberger JK . (2002). _Int. Immunol._, 14, 1383–1395. Download references ACKNOWLEDGEMENTS We thank Terryl Stacy

for critically reading the manuscript, and Ellen Rothenberg and Rudi Hendriks for their helpful comments. We dedicate this article to the late Hisamaru Hirai, whose outstanding contribution

to the study of Runx1 function in adult hematopoiesis both inspired and provided the focal point for this review. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * MRC Molecular Haematology

Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK Marella FTR de Bruijn * Department of Biochemistry, Dartmouth Medical School, Hanover, 03755,

NH, USA Nancy A Speck Authors * Marella FTR de Bruijn View author publications You can also search for this author inPubMed Google Scholar * Nancy A Speck View author publications You can

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de Bruijn, M., Speck, N. Core-binding factors in hematopoiesis and immune function. _Oncogene_ 23, 4238–4248 (2004). https://doi.org/10.1038/sj.onc.1207763 Download citation * Published: 24

May 2004 * Issue Date: 24 May 2004 * DOI: https://doi.org/10.1038/sj.onc.1207763 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable

link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Runx1 * Runx2 *

Runx3 * CBF_β_ * AML1 * hematopoiesis * hematopoietic stem cells