ABSTRACT The cysteine protease caspase-8 plays a pivotal role in the initiation of different apoptotic pathways and controls the maturation and differentiation of various cell types

including neurons, fibroblasts and lymphocytes. Specific substrates of caspase-8 are present in both the cytoplasm and the nucleus, which may determine the ultimate biological effect of

caspase-8. However, the mechanisms regulating the cellular localization of caspase-8 are still unknown. We show here that, in contrast to other caspases such as caspase-9 and -3, caspase-8

can be sumoylated at lysine 156. This sumoylation (i) is associated with the nuclear localization of caspase-8 and (ii) did not impair caspase-8 activation. Access through your institution

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OTHERS ALLY OR TRAITOR: THE DUAL ROLE OF P62 IN CASPASE-2 REGULATION Article Open access 14 November 2024 CASPASE-8 DEFICIENCY INDUCES A SWITCH FROM TLR3 INDUCED APOPTOSIS TO LYSOSOMAL CELL

DEATH IN NEUROBLASTOMA Article Open access 19 May 2021 LINC COMPLEX PROTEIN NESPRIN-2 HAS PRO-APOPTOTIC ACTIVITY VIA BCL-2 FAMILY PROTEINS Article Open access 15 January 2024 REFERENCES *

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Download references ACKNOWLEDGEMENTS This work was supported by INSERM and by grants from the Fondation de France and Association pour la Recherche sur le Cancer (ARC). L Besnault-Mascard

holds fellowships from Fondation pour la Recherche Médicale (2001–2002) and Académie Nationale de Médecine (2002–2003). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * INSERM U542, Hôpital

Paul Brousse, Bâtiment Lavoisier, 14 Avenue Paul Vaillant Couturier, 94807, Villejuif cedex, France Laurence Besnault-Mascard, Marie Thérèse Auffredou, Marie Françoise Bourgeade, Hans

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ARTICLE CITE THIS ARTICLE Besnault-Mascard, L., Leprince, C., Auffredou, M. _et al._ Caspase-8 sumoylation is associated with nuclear localization. _Oncogene_ 24, 3268–3273 (2005).

https://doi.org/10.1038/sj.onc.1208448 Download citation * Received: 04 November 2004 * Revised: 01 December 2004 * Accepted: 14 December 2004 * Published: 14 March 2005 * Issue Date: 05 May

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is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * caspase * SUMO * nuclear localization *

apoptosis * human