ABSTRACT Despite major interest in sodium iron (III) ethylenediaminetetraacetic acid's (EDTA) potential use in food fortification programs in potentially curbing the global problem of

iron deficiency and its anemia, synthesis methods of stable isotope-labeled sodium iron (III) EDTA for use in human bioavailability studies are incomplete, incorrect or totally lacking.

Owing to a number of clinical research groups requiring this compound in bioavailability studies, in both developing and already developed countries, we simplified and optimized the

synthesis of sodium iron (III) EDTA from a block of isotopically enriched iron metal, in order that it be easily reproduced, cheaply, using simple basic laboratory apparatus. The resulting

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IRON FROM NANOSTRUCTURED FERRIC PHOSPHATE: ABSORPTION AND BIODISTRIBUTION IN MICE AND BIOAVAILABILITY IN IRON DEFICIENT ANEMIC WOMEN Article Open access 18 February 2022 ALTERNATE DAY

VERSUS DAILY ORAL IRON FOR TREATMENT OF IRON DEFICIENCY ANEMIA: A RANDOMIZED CONTROLLED TRIAL Article Open access 01 February 2023 A PROPOSED METHOD FOR DEFINING THE REQUIRED FORTIFICATION

LEVEL OF MICRONUTRIENTS IN FOODS: AN EXAMPLE USING IRON Article 08 September 2022 REFERENCES * ACC/SCN (2004). _5th Report on the World Nutrition Situation_. ACC/SCN & IFPRI: Geneva,

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of disodium EDTA. _J Nutr_ 133, 3158–3161. Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We would thank Mr E Erasmus at North-West University Biochemistry (South Africa)

and Ms C de Wolf at Akzo Nobel laboratories (The Netherlands) for the electrospray ionization mass spectrometry and capillary zone electrophoresis purity analyses of the synthesized product

and the International Atomic Energy Association (IAEA) who kindly supplied the stable iron isotope metal (57Fe and 58Fe). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Nutrition, School of Physiology, Nutrition and Consumer Sciences, North-West University, Potchefstroom, South Africa Du T Loots & M V Lieshout * Department of Chemistry, School of

Chemistry and Biochemistry, North-West University, Potchefstroom, South Africa G Lachmann Authors * Du T Loots View author publications You can also search for this author inPubMed Google

Scholar * M V Lieshout View author publications You can also search for this author inPubMed Google Scholar * G Lachmann View author publications You can also search for this author inPubMed

 Google Scholar CORRESPONDING AUTHOR Correspondence to Du T Loots. ADDITIONAL INFORMATION _Guarantor:_ DT Loots. _Contributors:_ DTL was the main writer and was involved in the entire

research process, MvL assisted in the method development and writing and GL was approached in an advisory capacity as inorganic chemist regarding the method developed. RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Loots, D., Lieshout, M. & Lachmann, G. Sodium iron (III) ethylenediaminetetraacetic acid synthesis to reduce iron

deficiency globally. _Eur J Clin Nutr_ 61, 287–289 (2007). https://doi.org/10.1038/sj.ejcn.1602499 Download citation * Received: 25 January 2006 * Revised: 31 May 2006 * Accepted: 31 May

2006 * Published: 02 August 2006 * Issue Date: 01 February 2007 * DOI: https://doi.org/10.1038/sj.ejcn.1602499 SHARE THIS ARTICLE Anyone you share the following link with will be able to

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initiative KEYWORDS * stable isotope * sodium iron (III) EDTA * bioavailability * iron * deficiency