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ABSTRACT THE extension of the Michaelis–Menten theory to a mixture of two substrates and an enzyme which attacks both given by Thorn1 has also been worked out by us and appears in a
publication now in the press2. We have given a method of obtaining the ratio of the Michaelis constants which is simpler than his. Using Thorn's symbols, his last equation but one
simplifies to where V_m_ is the maximum initial velocity of the mixed substrates. This equation can be transformed into, the equation Access through your institution Buy or subscribe This is
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2024 REFERENCES * Thorn, M. B., _Nature_, 164, 27 (1949). Article ADS CAS Google Scholar * Adams, D. H., and Whittaker, V. P., _Biochim. et Biophys. Acta_ (in the press). Download
references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biochemistry, University of Oxford. London Hospital, London, E.1 V. P. WHITTAKER & D. H. ADAMS Authors * V. P.
WHITTAKER View author publications You can also search for this author inPubMed Google Scholar * D. H. ADAMS View author publications You can also search for this author inPubMed Google
Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE WHITTAKER, V., ADAMS, D. A Method for Determining the Ratio of the Michael is Constants of an
Enzyme with Respect to Two Substrates. _Nature_ 164, 315–316 (1949). https://doi.org/10.1038/164315a0 Download citation * Issue Date: 20 August 1949 * DOI: https://doi.org/10.1038/164315a0
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