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ABSTRACT Cardiac complications may result from high-dose chemotherapy or irradiation administered during the conditioning phase of bone marrow and blood stem cell transplantation (BMT). To
assess the frequency of clinically serious cardiac toxicity related to the acute phase of BMT, we retrospectively examined life-threatening or fatal cardiotoxicity identified using the
complications records of our transplant center clinical database. All serious cardiac toxicity events within 100 days of BMT except those attributable to septic shock, pneumonitis or
multi-organ failure were reviewed. Of 2821 BMT patients at the University of Minnesota between 1977 and 1997, 26 were identified as having suffered major or fatal (_n_ = 13) cardiotoxicity
(0.9%, 19 adults and seven children). Rapidly progressive heart failure resulted in death of 11 patients, one patient had fatal pericardial tamponade, and one had an acute ventricular
fibrillation arrest. The remaining 13 patients (50%) had life-threatening cardiotoxicity including four patients with pericardial tamponade and nine patients with cardiac arrhythmias.
Overall, we observed that acute, major cardiotoxic events attributable to BMT are uncommon, occurring with a frequency of <1%. These data suggest that with appropriate pre-transplant
clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity. _Bone Marrow
Transplantation_ (2001) 28, 283–287. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through
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Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CARDIAC EVENTS OCCURRING AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION WITH POST-TRANSPLANT
CYCLOPHOSPHAMIDE. STUDY CONDUCTED ON BEHALF OF THE GETH-TC Article 14 September 2024 INFECTIOUS COMPLICATIONS AFTER SECOND ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT IN ADULT PATIENTS WITH
HEMATOLOGICAL MALIGNANCIES Article 23 September 2022 LIFE EXPECTANCY AND BURDEN OF LATE COMPLICATIONS AFTER REDUCED INTENSITY CONDITIONING ALLOGENEIC TRANSPLANTATION Article 02 June 2022
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AND AFFILIATIONS * Blood and Marrow Transplant Program, and Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA T Murdych & DJ Weisdorf Authors * T Murdych View
author publications You can also search for this author inPubMed Google Scholar * DJ Weisdorf View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Murdych, T., Weisdorf, D. Serious cardiac complications during bone marrow transplantation at the University of
Minnesota, 1977–1997. _Bone Marrow Transplant_ 28, 283–287 (2001). https://doi.org/10.1038/sj.bmt.1703133 Download citation * Received: 26 October 2000 * Accepted: 05 April 2001 * Published:
04 September 2001 * Issue Date: 01 August 2001 * DOI: https://doi.org/10.1038/sj.bmt.1703133 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:
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cardiac * marrow transplant * toxicity