ABSTRACT In the bone marrow transplant setting, several authors hypothesized that severely overweight patients are at increased risk of transplant-related toxicity, but different definitions

of obesity, different body weight groupings and heterogeneous samples of patients were analyzed. To overcome these limitations, we retrospectively considered a homogeneous group of 54

patients (median age 36.5 years), with a diagnosis of _de novo_ acute myeloid leukemia (AML), autografted in first complete remission (CR) with the Bu-Cy2 conditioning regimen, dosed on

actual body weight. Patients were classified into three groups (obese, non-obese, underweight) using body mass index (BMI = kg/m2); for each group we analyzed transplant-related toxicity and

significant differences in OS and DFS were detected between obese and non-obese groups (_P_ = 0.012 and 0.021, respectively). Our study sugggests that obesity may represent an independent

risk factor for autograft in AML and further investigations are warranted. _Bone Marrow Transplantation_ (2001) 28, 365–367 Access through your institution Buy or subscribe This is a preview

of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only

$21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during

checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ASSOCIATION BETWEEN

CLASS III OBESITY AND OVERALL SURVIVAL IN PREVIOUSLY UNTREATED YOUNGER PATIENTS WITH ACUTE MYELOID LEUKEMIA ENROLLED ON SWOG S1203 Article 03 June 2024 THE IMPACT OF PRE-TRANSPLANTATION

DIABETES AND OBESITY ON ACUTE GRAFT-VERSUS-HOST DISEASE, RELAPSE AND DEATH AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION: A STUDY FROM THE EBMT TRANSPLANT COMPLICATIONS WORKING PARTY

Article Open access 07 December 2023 THE ASSOCIATION OF BODY COMPOSITION AND OUTCOMES FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENTS WITH NON-HODGKIN LYMPHOMA

Article 12 September 2023 REFERENCES * Champlin RE, Gale RP . The early complications of bone marrow transplantation _Semin Hematol_ 1984 21: 101–108 CAS  PubMed  Google Scholar  * Deeg HJ .

Delayed complications after bone marrow transplantation In: Forman S, Blume K, Thomas E (eds) _Bone Marrow Transplantation_ Blackwell Scientific Pubblications: Boston 1994 pp 538–544 Google

Scholar  * Bearman SI, Appelbaum FR, Buckner CD _et al_. Regimen-related toxicity in patients undergoing bone marrow transplantation _J Clin Oncol_ 1988 6: 1562–1568 Article  CAS  Google

Scholar  * Miller CB, Piantadosi S, Vogelsang GB _et al_. Impact of age on outcome of patients with cancer undergoing autologous bone marrow transplant _J Clin Oncol_ 1996 14: 1327–1332

Article  CAS  Google Scholar  * Hertenstein B, Stefanic M, Schmeiser T _et al_. Cardiac toxicity of bone marrow transplantation: predictive value of cardiologic evaluation before transplant

_J Clin Oncol_ 1994 12: 998–1004 Article  CAS  Google Scholar  * McDonald GB, Hinds MS, Fisher LD _et al_. Veno-occlusive disease of the liver and multiorgan failure after bone marrow

transplantation: a cohort study of 355 patients _Ann Intern Med_ 1993 118: 255–267 Article  CAS  Google Scholar  * Pi-Sunyer FX . Medical hazards of obesity _Ann Intern Med_ 1993 119:

655–660 Article  CAS  Google Scholar  * Coghlin Dickson TM, Kusnierz-Glaz CR, Blume KG _et al_. Impact of admission body weight and chemotherapy dose adjustment on the outcome of autologous

bone marrow transplantation _Biol Blood Marrow Transplant_ 1999 5: 299–305 Article  Google Scholar  * Deeg HJ, Seidel K, Bruemmer B _et al_. Impact of patient weight on non-relapse mortality

after marrow transplantation _Bone Marrow Transplant_ 1995 15: 461–468 CAS  PubMed  Google Scholar  * Fleming DR, Rayens MK, Garrison J . Impact of obesity on allogeneic cell transplant

patients: a matched case-controlled study _Am J Med_ 1997 102: 265–268 Article  CAS  Google Scholar  * Kobayashi K, Ratain MJ . Individualizing dosing of cancer chemotherapy _Semin Oncol_

1993 20: 30–42 CAS  PubMed  Google Scholar  * Cox J, Penn N, Masood M _et al_. Drug over-dose – a hidden hazard of obesity _J R Soc Med_ 1987 80: 708–709 Article  CAS  Google Scholar  *

Cheymol G . Drug pharmacokinetics in the obese _Fundam Clin Pharmacol_ 1988 2: 239–256 Article  CAS  Google Scholar  * Smith TJ, Desch CE . Neutropenia-wise and pound-foolish: safe and

effective chemotherapy in massively obese patients _South Med J_ 1991 84: 883–885 Article  CAS  Google Scholar  * Powis G, Reece P, Ahmann DL, Ingle JN . Effect of body weight on the

pharmacokinetics of cyclophosphamide in breast cancer patients _Cancer Chemother Pharmacol_ 1987 20: 219–222 Article  CAS  Google Scholar  * Geprgiadis MS, Steinberg SM, Hankins LA _et al_.

Obesity and therapy-related toxicity in patients treated for small-cell lung cancer _J Natl Cancer Inst_ 1995 87: 361–366 Article  Google Scholar  * Bastarrachea J, Hortobagyi GN, Smith TL

_et al_. Obesity as an adverse prognostic factor for patients receiving adjuvant chemotherapy for breast cancer _Ann Intern Med_ 1994 120: 18–25 Article  CAS  Google Scholar  * Grigg A,

Harum MH, Szer J . Variability in dermination of body weight used for dosing busulphan and cyclophosphamide in adult patients: results of an international survey _Leuk Lymphoma_ 1997 25:

487–491 Article  CAS  Google Scholar  * Benn RT . Indices of height and weight as measures of obesity _Br J Prev Soc Med_ 1970 24: 64 CAS  PubMed  PubMed Central  Google Scholar  * Bennett

JM, Catovsky D, Daniel MT _et al_. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French–American–British Cooperative Group _Ann Intern Med_ 1985

103: 620–625 Article  CAS  Google Scholar  * Santos GW, Tutschka PJ, Brookmayer R _et al_. Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulphan and

cyclophosphamide _New Engl J Med_ 1983 309: 1347–1353 Article  CAS  Google Scholar  * Tutschka PJ, Copelan EA, Klein JP . Bone marrow transplantation for leukemia following a new busulphan

and cyclophosphamide regimen _Blood_ 1987 70: 1387–1388 Google Scholar  * World Health Organization . _WHO handbook for reporting results of cancer treatment_ World Health Organization:

Geneva, Switzerland 1979 Google Scholar  * Kaplan E, Meier P . Nonparametric estimation from incomplete observations _J Am Stat Assoc_ 1958 53: 457–481 Article  Google Scholar  * Peto R,

Pike MC, Armitage P _et al_. Design and analysis of randomized clinical trials requiring prolonged observations of each patient. II Analysis and examples _Br J Cancer_ 1977 35: 1–39 Article

  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported by MURST 40% and FIRC. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biotecnologie Cellulari

ed Ematologia, University ‘La Sapienza’, Roma, Italy G Meloni, A Proia, S Capria, A Romano, G Trapé, SM Trisolini, M Vignetti & F Mandelli Authors * G Meloni View author publications

You can also search for this author inPubMed Google Scholar * A Proia View author publications You can also search for this author inPubMed Google Scholar * S Capria View author publications

You can also search for this author inPubMed Google Scholar * A Romano View author publications You can also search for this author inPubMed Google Scholar * G Trapé View author

publications You can also search for this author inPubMed Google Scholar * SM Trisolini View author publications You can also search for this author inPubMed Google Scholar * M Vignetti View

author publications You can also search for this author inPubMed Google Scholar * F Mandelli View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Meloni, G., Proia, A., Capria, S. _et al._ Obesity and autologous stem cell transplantation in acute myeloid

leukemia. _Bone Marrow Transplant_ 28, 365–367 (2001). https://doi.org/10.1038/sj.bmt.1703145 Download citation * Received: 03 January 2001 * Accepted: 11 May 2001 * Published: 18 September

2001 * Issue Date: 01 August 2001 * DOI: https://doi.org/10.1038/sj.bmt.1703145 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable

link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * autograft * AML *

obesity