ABSTRACT Although the use of non-myeloablative stem cell transplantation (NST) reduces the severity of graft-versus-host disease (GVHD), GVHD remains a major complication following

allogeneic transplantation. Since following NST in comparison with myeloablative conditioning, higher proportions of host immunohematopoietic cells may persist while donor-derived

alloreactive lymphocytes are being infused, thus possibly serving as host antigen presentation for continuous stimulation of donor T cells, we speculated that GVHD may be similarly amplified

by conditioning followed by intentional administration of host cells. This hypothesis was tested in a preclinical animal model. Increased incidence of GVHD, higher mortality and increased

higher than anticipated incidence of GVHD and rapid displacement of host cells and conversion to 100% donor type cells following NST. Administration of irradiated host antigen-presenting

cells post transplantation may thus represent a potential approach for amplification of the alloreactive capacity of donor lymphocytes following stem cell transplantation. Access through

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CONTENT BEING VIEWED BY OTHERS DYNAMIC IMMUNE PROFILING IDENTIFIES THE STRONGER GRAFT-VERSUS-LEUKEMIA (GVL) EFFECTS WITH HAPLOIDENTICAL ALLOGRAFTS COMPARED TO HLA-MATCHED STEM CELL

TRANSPLANTATION Article 06 January 2021 HOW ADOPTIVE TRANSFER OF COMPONENTS OF THE DONOR IMMUNE SYSTEM BOOSTS GVL AND PREVENTS GVHD IN HLA-HAPLOIDENTICAL HEMATOPOIETIC TRANSPLANTATION FOR

ACUTE LEUKEMIA Article 11 January 2024 REMOVAL OF CD276+ CELLS FROM HAPLOIDENTICAL MEMORY T-CELL GRAFTS SIGNIFICANTLY LOWERS THE RISK OF GVHD Article Open access 11 May 2021 REFERENCES *

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Rich Leukemia Research Foundation; the Cancer Treatment Research Foundation; the Novotny Trust; the Szydlowsky Foundation; The Fig Tree Foundation; Ronne & Donald Hess and the

Silverstein Families for their continuous support of our basic and clinical research. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Bone Marrow Transplantation and Cancer

Immunotherapy, Hadassah – Hebrew University Medical Center, Jerusalem, Israel E Hirshfeld, L Weiss, J Kasir, M Zeira, S Slavin & M Y Shapira Authors * E Hirshfeld View author

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AUTHOR Correspondence to M Y Shapira. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hirshfeld, E., Weiss, L., Kasir, J. _et al._ Post transplant

persistence of host cells augments the intensity of acute graft-versus-host disease and level of donor chimerism, an explanation for graft-versus-host disease and rapid displacement of host

cells seen following non-myeloablative stem cell transplantation?. _Bone Marrow Transplant_ 38, 359–364 (2006). https://doi.org/10.1038/sj.bmt.1705449 Download citation * Received: 24 April

2006 * Revised: 06 June 2006 * Accepted: 23 June 2006 * Published: 24 July 2006 * Issue Date: 01 September 2006 * DOI: https://doi.org/10.1038/sj.bmt.1705449 SHARE THIS ARTICLE Anyone you

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Springer Nature SharedIt content-sharing initiative KEYWORDS * graft-versus-host disease * non-myeloablative stem cell transplantation * chimerism * antigen presentation