Long-term suppression of a permeability response of the rat's hind-paw by cortisone,by hypophysectomy and by protein-deficient diet

Long-term suppression of a permeability response of the rat's hind-paw by cortisone,by hypophysectomy and by protein-deficient diet

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ABSTRACT SOME three years ago, we reported that crude testicular extracts containing hyaluronidase greatly increase permeability in the rat's hind-paw1. 0.3–0.8 mgm. of crude extract is dissolved in 0.11 ml. saline and injected at the plantar side; each animal serves as its own control. The acute œdema—surpassing that caused by the usual doses of dextran—contains 4.0–5.5 gm. protein per 100 ml. The presence of histamine was demonstrated by the guinea pig ileum test as well as by partition paper chromatography, the concentration being 2.5–4.5 µgm. per ml. The significance of this histamine, as well as the influence of local reactivity of the tissues of the hind-paw, and the influence of age differences will be discussed separately. We find that young rats regularly show ‘full’ œdemas in our colony, although the response tends to diminish gradually with advancing age. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CHEMOPROTECTIVE EFFECTS OF INOSITOL HEXAPHOSPHATE AGAINST CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS Article Open access 28 July 2020 GLUCOCORTICOIDS INCREASE TISSUE CELL PROTECTION AGAINST PORE-FORMING TOXINS FROM PATHOGENIC BACTERIA Article Open access 17 February 2023 REVISITING STEROIDOGENESIS AND ITS ROLE IN IMMUNE REGULATION WITH THE ADVANCED TOOLS AND TECHNOLOGIES Article Open access 14 June 2021 REFERENCES * Kelemen, E., Majoros, M., and Iványi, J., _Acta Med. Hungarica_, 2, 201 (1951). CAS  Google Scholar  * Tanos, B., Soltész, R., and Kelemen, E., _Acta Med. Hungarica_, 4, 419 (1953). CAS  Google Scholar  * Kelemen, E., Tanos, B., Soltész, R., and Kovács, K., _Acta Endocrin._, 13, 231 (1953). Article  CAS  Google Scholar  * Kelemen, E., _Brit. Med. J._, ii, 301 (1954). * Kelemen, E., Oláh, F., and Majoros, M., _Lancet_, ii, 886 (1951). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * I. Belgyógyászati Clinic, Szeged, Hungary E. KELEMEN, B. TANOS, L. HAJDU & P. FORGÁCS Authors * E. KELEMEN View author publications You can also search for this author inPubMed Google Scholar * B. TANOS View author publications You can also search for this author inPubMed Google Scholar * L. HAJDU View author publications You can also search for this author inPubMed Google Scholar * P. FORGÁCS View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE KELEMEN, E., TANOS, B., HAJDU, L. _et al._ Long-term Suppression of a Permeability Response of the Rat's Hind-paw by Cortisone,by Hypophysectomy and by Protein-deficient Diet. _Nature_ 175, 122–123 (1955). https://doi.org/10.1038/175122a0 Download citation * Issue Date: 15 January 1955 * DOI: https://doi.org/10.1038/175122a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT SOME three years ago, we reported that crude testicular extracts containing hyaluronidase greatly increase permeability in the rat's hind-paw1. 0.3–0.8 mgm. of crude extract is


dissolved in 0.11 ml. saline and injected at the plantar side; each animal serves as its own control. The acute œdema—surpassing that caused by the usual doses of dextran—contains 4.0–5.5


gm. protein per 100 ml. The presence of histamine was demonstrated by the guinea pig ileum test as well as by partition paper chromatography, the concentration being 2.5–4.5 µgm. per ml. The


significance of this histamine, as well as the influence of local reactivity of the tissues of the hind-paw, and the influence of age differences will be discussed separately. We find that


young rats regularly show ‘full’ œdemas in our colony, although the response tends to diminish gradually with advancing age. Access through your institution Buy or subscribe This is a


preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per


year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during


checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CHEMOPROTECTIVE


EFFECTS OF INOSITOL HEXAPHOSPHATE AGAINST CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS Article Open access 28 July 2020 GLUCOCORTICOIDS INCREASE TISSUE CELL PROTECTION AGAINST


PORE-FORMING TOXINS FROM PATHOGENIC BACTERIA Article Open access 17 February 2023 REVISITING STEROIDOGENESIS AND ITS ROLE IN IMMUNE REGULATION WITH THE ADVANCED TOOLS AND TECHNOLOGIES


Article Open access 14 June 2021 REFERENCES * Kelemen, E., Majoros, M., and Iványi, J., _Acta Med. Hungarica_, 2, 201 (1951). CAS  Google Scholar  * Tanos, B., Soltész, R., and Kelemen, E.,


_Acta Med. Hungarica_, 4, 419 (1953). CAS  Google Scholar  * Kelemen, E., Tanos, B., Soltész, R., and Kovács, K., _Acta Endocrin._, 13, 231 (1953). Article  CAS  Google Scholar  * Kelemen,


E., _Brit. Med. J._, ii, 301 (1954). * Kelemen, E., Oláh, F., and Majoros, M., _Lancet_, ii, 886 (1951). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * I. Belgyógyászati


Clinic, Szeged, Hungary E. KELEMEN, B. TANOS, L. HAJDU & P. FORGÁCS Authors * E. KELEMEN View author publications You can also search for this author inPubMed Google Scholar * B. TANOS


View author publications You can also search for this author inPubMed Google Scholar * L. HAJDU View author publications You can also search for this author inPubMed Google Scholar * P.


FORGÁCS View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE KELEMEN, E.,


TANOS, B., HAJDU, L. _et al._ Long-term Suppression of a Permeability Response of the Rat's Hind-paw by Cortisone,by Hypophysectomy and by Protein-deficient Diet. _Nature_ 175, 122–123


(1955). https://doi.org/10.1038/175122a0 Download citation * Issue Date: 15 January 1955 * DOI: https://doi.org/10.1038/175122a0 SHARE THIS ARTICLE Anyone you share the following link with


will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt


content-sharing initiative