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Biochemical tests for malignancy applied to a new strain of human cells

Biochemical tests for malignancy applied to a new strain of human cells

Biochemical tests for malignancy applied to a new strain of human cells

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ABSTRACT TRANSFORMATIONS of normal cells of rats and mice into malignant strains have been reported to occur under tissue culture conditions on a few occasions1, and in such cases it was possible to demonstrate their malignancy by inoculation into the appropriate animal strains. During tissue-culture experiments with human cells, an abnormal strain appeared in roller-tubes of liver cells from a 20-week embryo. The new strain showed some of the characteristics of malignant cells, and we had to rely on biochemical tests to obtain further evidence of their malignancy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS HUMAN CELL TRANSFORMATION BY COMBINED LINEAGE CONVERSION AND ONCOGENE EXPRESSION Article Open access 23 July 2021 EXPRESSION OF G PROTEIN-COUPLED RECEPTOR GPR19 IN NORMAL AND NEOPLASTIC HUMAN TISSUES Article Open access 03 November 2023 THE CELL-LINE-DERIVED SUBCUTANEOUS TUMOR MODEL IN PRECLINICAL CANCER RESEARCH Article 20 July 2022 REFERENCES * Goldblatt, H., and Cameron, G., _J. Exp. Med._, 97, 525 (1953). Sanford, K. K., Likely, G. D., and Earle, W. R., _J. Nat. Cancer Inst._, 15, 215 (1954). Article  CAS  Google Scholar  * Healy, G. M., Fisher, D. C., and Parker, R. C., _Proc. Soc. Exp. Biol. Med._, 89, 71 (1955). Article  CAS  Google Scholar  * Vendrely, R., “_The Nucleic Acids_” (ed. Chargaff, E., and Davidson. J. N.), 2, Chap. 19 (Academic Press, 1955). Google Scholar  * Mellors, R. C., _Cancer Res._, 15, 557 (1955). CAS  PubMed  Google Scholar  * Weinhouse, S., “_Adv. Cancer Res._”, 3, 269 (1955). Article  CAS  Google Scholar  * Warburg, O., _Science_, 123, 309 (1956). Article  ADS  CAS  Google Scholar  * Woods, M. W., Wight, K., Hunter, J., and Burk, D., _Biochim. Biophys. Acta_, 12, 329 (1953). Article  CAS  Google Scholar  * Beck, W. S., and Valentine, W. N., _Cancer Res._, 13, 309 (1953). CAS  PubMed  Google Scholar  * Moore, A. E., Southam, C. M., and Sternberg, S. S., _Science_, 124, 127 (1956). Article  ADS  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Biochemistry Department, The Queen's University, Belfast I. LESLIE, W. C. FULTON & R. SINCLAIR Authors * I. LESLIE View author publications You can also search for this author inPubMed Google Scholar * W. C. FULTON View author publications You can also search for this author inPubMed Google Scholar * R. SINCLAIR View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE LESLIE, I., FULTON, W. & SINCLAIR, R. Biochemical Tests for Malignancy applied to a New Strain of Human Cells. _Nature_ 178, 1179–1180 (1956). https://doi.org/10.1038/1781179a0 Download citation * Issue Date: 24 November 1956 * DOI: https://doi.org/10.1038/1781179a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT TRANSFORMATIONS of normal cells of rats and mice into malignant strains have been reported to occur under tissue culture conditions on a few occasions1, and in such cases it was


possible to demonstrate their malignancy by inoculation into the appropriate animal strains. During tissue-culture experiments with human cells, an abnormal strain appeared in roller-tubes


of liver cells from a 20-week embryo. The new strain showed some of the characteristics of malignant cells, and we had to rely on biochemical tests to obtain further evidence of their


malignancy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe


to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF


Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact


customer support SIMILAR CONTENT BEING VIEWED BY OTHERS HUMAN CELL TRANSFORMATION BY COMBINED LINEAGE CONVERSION AND ONCOGENE EXPRESSION Article Open access 23 July 2021 EXPRESSION OF G


PROTEIN-COUPLED RECEPTOR GPR19 IN NORMAL AND NEOPLASTIC HUMAN TISSUES Article Open access 03 November 2023 THE CELL-LINE-DERIVED SUBCUTANEOUS TUMOR MODEL IN PRECLINICAL CANCER RESEARCH


Article 20 July 2022 REFERENCES * Goldblatt, H., and Cameron, G., _J. Exp. Med._, 97, 525 (1953). Sanford, K. K., Likely, G. D., and Earle, W. R., _J. Nat. Cancer Inst._, 15, 215 (1954).


Article  CAS  Google Scholar  * Healy, G. M., Fisher, D. C., and Parker, R. C., _Proc. Soc. Exp. Biol. Med._, 89, 71 (1955). Article  CAS  Google Scholar  * Vendrely, R., “_The Nucleic


Acids_” (ed. Chargaff, E., and Davidson. J. N.), 2, Chap. 19 (Academic Press, 1955). Google Scholar  * Mellors, R. C., _Cancer Res._, 15, 557 (1955). CAS  PubMed  Google Scholar  *


Weinhouse, S., “_Adv. Cancer Res._”, 3, 269 (1955). Article  CAS  Google Scholar  * Warburg, O., _Science_, 123, 309 (1956). Article  ADS  CAS  Google Scholar  * Woods, M. W., Wight, K.,


Hunter, J., and Burk, D., _Biochim. Biophys. Acta_, 12, 329 (1953). Article  CAS  Google Scholar  * Beck, W. S., and Valentine, W. N., _Cancer Res._, 13, 309 (1953). CAS  PubMed  Google


Scholar  * Moore, A. E., Southam, C. M., and Sternberg, S. S., _Science_, 124, 127 (1956). Article  ADS  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS


* Biochemistry Department, The Queen's University, Belfast I. LESLIE, W. C. FULTON & R. SINCLAIR Authors * I. LESLIE View author publications You can also search for this author


inPubMed Google Scholar * W. C. FULTON View author publications You can also search for this author inPubMed Google Scholar * R. SINCLAIR View author publications You can also search for


this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE LESLIE, I., FULTON, W. & SINCLAIR, R. Biochemical Tests for


Malignancy applied to a New Strain of Human Cells. _Nature_ 178, 1179–1180 (1956). https://doi.org/10.1038/1781179a0 Download citation * Issue Date: 24 November 1956 * DOI:


https://doi.org/10.1038/1781179a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently


available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative