Play all audios:
ABSTRACT A NUMBER of theories have recently been put forward to account for the carcinogenic activity of the polycyclic aromatic hydrocarbons; in their present form, the majority of these
theories do not provide a rationale for the fact that a number of chemically dissimilar carcinogens appear to operate through some common protein deletion principle1. Previous descriptions
of a possible mechanism of carcinogenesis2–4 have pointed out, however, that, in principle at least, the unifying mechanism by which such carcinogens act may be their formation of
charge-transfer complexes with proteins; we are now able to discuss the activities of the methyl-1,2-benzanthracenes and the mono-fluoro-10-methyl-1,2-benzanthracenes (Fig. 1) in such terms.
Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this
journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now
Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer
support SIMILAR CONTENT BEING VIEWED BY OTHERS THE MUTATIONAL SIGNATURE PROFILE OF KNOWN AND SUSPECTED HUMAN CARCINOGENS IN MICE Article 28 September 2020 INFLUENCE OF LIGAND’S DIRECTIONAL
CONFIGURATION, CHRYSENES AS MODEL COMPOUNDS, ON THE BINDING ACTIVITY WITH ARYL HYDROCARBON RECEPTOR Article Open access 14 August 2020 COMPUTATIONAL INSIGHTS INTO EXPLORING THE POTENTIAL
EFFECTS OF ENVIRONMENTAL CONTAMINANTS ON HUMAN HEALTH Article Open access 06 April 2025 REFERENCES * Heidelberger, C., and Moldenhauer, M. G., _Cancer Res._, 16, 442 (1956). CAS PubMed
Google Scholar * Mason, R., _Nature_, 181, 820 (1958). Article ADS CAS Google Scholar * Mason, R., _Brit. J. Cancer_, 12, 469 (1958). Article CAS Google Scholar * Mason, R., _Cahier
de Physique_, 124, 473 (1960). Google Scholar * Miller, E. C., and Miller, J. A., _Cancer Res._, 20, 133 (1960). CAS PubMed Google Scholar * Miller, E. C., and Miller, J. A., _Proc.
Amer. Assoc. Cancer Res._, 3, 134 (1960). Google Scholar * Davis, K. M. C., Eley, D. D., and Snart, R. S., _Nature_, 188, 724 (1960). Article ADS CAS Google Scholar Download references
AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Centre de Mécanique Ondulatoire, 155 Rue de Sèvres, Paris, 15 O. CHALVET & R. MASON * Department of Chemistry, Imperial College of Science
and Technology, London, S.W.7 O. CHALVET & R. MASON Authors * O. CHALVET View author publications You can also search for this author inPubMed Google Scholar * R. MASON View author
publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE CHALVET, O., MASON, R.
Carcinogenicity of the Methyl-1,2-Benzanthracenes and their Derivatives. _Nature_ 192, 1070–1072 (1961). https://doi.org/10.1038/1921070a0 Download citation * Issue Date: 16 December 1961 *
DOI: https://doi.org/10.1038/1921070a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative