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ABSTRACT Watson and Crick1 proposed as a possible mechanism for mutation that changes in the tautomeric structure of a base of deoxyribonucleic acid (DNA) could induce its pairing with an
anomalous base. In considering the possible correlation between the action of alkylating agents on DNA and the mutagenic activity of these agents, we mentioned in a recent report2 that it
was not obvious how the initial action of alkylation of DNA, which has been shown to occur at N(7) of guanine moieties3,4, could affect base-pairing in DNA according to the Watson–Crick
model. We therefore suggested that the subsequent loss of the alkylated guanine moiety from DNA (refs. 4 and 5) might be the chemical action necessary for mutation to result. Access through
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BEING VIEWED BY OTHERS PROTON TRANSFER DURING DNA STRAND SEPARATION AS A SOURCE OF MUTAGENIC GUANINE-CYTOSINE TAUTOMERS Article Open access 05 November 2022 THE TRAJECTORY OF INTRAHELICAL
LESION RECOGNITION AND EXTRUSION BY THE HUMAN 8-OXOGUANINE DNA GLYCOSYLASE Article Open access 07 September 2020 DYNAMIC BASIS FOR DA•DGTP AND DA•D8OGTP MISINCORPORATION VIA HOOGSTEEN BASE
PAIRS Article 24 April 2023 REFERENCES * Watson, J. D., and Crick, F. H. C., _Nature_, 171, 964 (1953). Article ADS CAS Google Scholar * Lawley, P. D., and Brookes, P., _Ann. Rep. Brit.
Empire Cancer Campaign_, 38, 10 (1960). Google Scholar * Lawley, P. D., and Wallick, C. A., _Chem. and Indust._, 633 (1957). * Brookes, P., and Lawley, P. D., _Biochem. J._, 77, 478 (1960).
Article CAS Google Scholar * Lawley, P. D., _Proc. Chem. Soc._, 290 (1957). * Brookes, P., and Lawley, P. D., _J. Chem. Soc._, 3923 (1961). Download references AUTHOR INFORMATION AUTHORS
AND AFFILIATIONS * Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London, S.W.3 P. D. LAWLEY & P. BROOKES Authors * P. D. LAWLEY
View author publications You can also search for this author inPubMed Google Scholar * P. BROOKES View author publications You can also search for this author inPubMed Google Scholar RIGHTS
AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE LAWLEY, P., BROOKES, P. Acidic Dissociation of 7 : 9-Dialkylguanines and its Possible Relation to Mutagenic
Properties of Alkylating Agents. _Nature_ 192, 1081–1082 (1961). https://doi.org/10.1038/1921081b0 Download citation * Issue Date: 16 December 1961 * DOI: https://doi.org/10.1038/1921081b0
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