Play all audios:
ABSTRACT THE human erythrocyte normally survives in the circulation approximately 120 days. The factors which limit the cell's survival are unknown. An important factor may be an
age-related diminution in the activity of one or more enzymes vital to the cell1. A decrease in the activity of a key glycolytic enzyme, or enzymes, might be of particular importance because
the mature human red cell derives virtually all its energy through glycolysis. Certain inherited enzymatic defects, both in the anaerobic glycolytic and in the pentose phosphate pathways of
the human red cell, are associated with shortening of the lifespan of the cell2–5. Access through your institution Buy or subscribe This is a preview of subscription content, access via
your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this
article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in
* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ESTIMATION OF THE HEMOGLOBIN GLYCATION RATE CONSTANT Article Open
access 13 January 2021 QUANTIFYING THE EFFECT OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE DEFICIENCY ON GLYCATED HEMOGLOBIN VALUES IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES Article Open
access 27 March 2024 EVALUATION OF THE MAIN REGULATORS OF SYSTEMIC IRON HOMEOSTASIS IN PYRUVATE KINASE DEFICIENCY Article Open access 16 March 2023 REFERENCES * Eadie, G. S., and Brown,
jun., I. W., _Blood_, 82, 1110 (1953). Google Scholar * Newton, jun., W. A., and Bass, J. C., _Amer. Med. Assoc. J. Dis. Child._, 96, 501 (1958). Google Scholar * Brewer, G. J., Tarlov, A.
R., and Kellermeyer, R. W., _J. Lab. and Clin. Med._, 58, 217 (1961). CAS Google Scholar * Valentine, W. N., Tanaka, K. R., and Miwa, S., _Trans. Assoc. Amer. Phys._, 74, 100 (1961). CAS
Google Scholar * Carson, P. E., Brewer, G. J., and Ickes, C., _J. Lab. and Clin. Med._, 58, 804 (1961). Google Scholar * Allison, A. C., and Burn, G. P., _Brit. J. Hœmat._, 1, 291
(1955). Article CAS Google Scholar * Marks, P. A., Johnson, A. B., and Hirschberg, E., _Proc. U.S. Nat. Acad. Sci._, 44, 529 (1958). Article CAS ADS Google Scholar * Lohr, G. W.,
Waller, H. G., Kargas, O., Schlegal, B., and Muller, A. A., _Klin. Wschr._, 36, 1008 (1958). Article CAS Google Scholar * Berstein, R. A., _J. Clin. Invest._, 38, 1572 (1959). Article
Google Scholar * Prankerd, T. A. J., _The Red Cell: An Account of its Chemical Physiology and Pathology_ (Thomas, Springfield, Illinois, 1961). Google Scholar * Powell, R. D., and Brewer,
G. J., _Klin. Wschr._, 41, 200 (1963). Article CAS Google Scholar * Schrier, S. L., Kellermeyer, R. W., Carson, P. E., Ickes, C. E., and Alving, A. S., _J. Lab. and Clin. Med._, 54, 232
(1959). CAS Google Scholar * Chapman, R. G., Hennessey, M. A., Waltersdorph, A. M., Huennekens, F. M., and Gabrio, B. W., _J. Clin. Invest._, 41, 1249 (1962). Article CAS Google Scholar
* Scheuch, D., Kahrig, C., Ockel, E., Wageneneeht, C., and Rapoport, S. M., _Nature_, 190, 631 (1961). Article CAS ADS Google Scholar * Brewer, G. J., Tarlov, A. R., Kellermeyer, R.
W., and Alving, A. S., _J. Lab. and Clin. Med._, 59, 905 (1962). CAS Google Scholar * Brewer, G. J., Powell, R. D., and Alving, A. S. (in preparation). * Slein, M. W., Cori, G. T., and
Cori, C. F., _J. Biol. Chem._, 186, 763 (1950). CAS PubMed Google Scholar * Glock, G. E., and McLean, P., _Biochem. J._, 55, 400 (1953). Article CAS Google Scholar * Zinkham, W. H.,
and Lenhard, R. E., _J. Pediat._, 55, 319 (1959). Article CAS Google Scholar * Borun, E. R., Figueroa, W. G., and Perry, S. M., _J. Clin. Invest._, 36, 676 (1957). Article CAS Google
Scholar * Prankerd, T. A. J., _J. Physiol._, 143, 325 (1958). Article CAS Google Scholar * Rigas, D. A., and Koler, R. D., _J. Lab. and Clin. Med._, 58, 242 (1961). CAS Google Scholar
* Marks, P. A., and Gross, R. T., _J. Clin. Invest._, 38, 2253 (1959). Article CAS Google Scholar * Brewer, G. J., and Powell, R. D. (personal observations). * Brewer, G. J., Powell, R.
D., and Alving, A. S., _J. Lab. and Clin. Med._, 60, 861 (1962). Google Scholar * Fisher, R. A., _Statistical Methods for Research Workers_ (Hafner, New York, 1958). MATH Google Scholar
Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Army Medical Research Unit, Department of Medicine, University of Chicago, GEORGE J. BREWER & ROBIN D. POWELL Authors *
GEORGE J. BREWER View author publications You can also search for this author inPubMed Google Scholar * ROBIN D. POWELL View author publications You can also search for this author inPubMed
Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BREWER, G., POWELL, R. Hexokinase Activity as a Function of Age of the Human Erythrocyte.
_Nature_ 199, 704–705 (1963). https://doi.org/10.1038/199704a0 Download citation * Issue Date: 17 August 1963 * DOI: https://doi.org/10.1038/199704a0 SHARE THIS ARTICLE Anyone you share the
following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer
Nature SharedIt content-sharing initiative