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ABSTRACT PREVIOUS reports have shown that penicillinase (β-lactamase) is not an inducible enzyme in strains of _Escherichia coli, Klebsiella_ and _Aerobacter_; but _Proteus_ species have not
been investigated1–3. There is also a species variation in penicillinase activity with different substrates3. Cephalosporinase activity has been described in many species of gram-negative
bacilli4 and is associated with cephalosporin resistance in _Proteus_ species5. In the work recorded here, inducibility of Cephalosporinase and penicillinase was investigated in strains of
_Proteus morgani, P. vulgaris, P. rettgeri_ and _P. mirabilis_. The strains were all resistant to ampicillin ((D(–)α-aminophenylacetamido)-penicillanic acid) and cephalothin
((7-thiophene-2-acet-amido)-cephalosporanic acid), apart from _P. mirabilis_ which was sensitive to cephalothin. Many strains of _P. mirabilis_ are also sensitive to ampicillin, but these
were not included in the present investigation as they either inactivate benzylpenicillin or cephalosporin slowly or not at all. Access through your institution Buy or subscribe This is a
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BACTERIOCIN OF _STREPTOCOCCUS ANGINOSUS_ Article Open access 21 December 2021 FILLING KNOWLEDGE GAPS RELATED TO AMPC-DEPENDENT Β-LACTAM RESISTANCE IN _ENTEROBACTER CLOACAE_ Article Open
access 02 January 2024 COMPREHENSIVE ANALYSIS OF BACTERIOCINS PRODUCED BY CLINICAL ENTEROCOCCAL ISOLATES AND THEIR ANTIBACTERIAL ACTIVITY AGAINST ENTEROCOCCI INCLUDING VRE Article Open
access 09 February 2025 REFERENCES * Smith, J. T., _J. Gen. Microbiol._, 30, 299 (1963). Article CAS Google Scholar * Ayliffe, G. A. J., _J. Gen. Microbiol._, 30, 339 (1963). Article CAS
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ADS CAS Google Scholar * Hamilton-Miller, J. M. T., _Biochem. Biophys. Res. Comm._, 13, 43 (1963). Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND
AFFILIATIONS * Department of Bacteriology, Postgraduate Medical School, Hammersmith, London, W.12 G. A. J. AYLIFFE Authors * G. A. J. AYLIFFE View author publications You can also search for
this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE AYLIFFE, G. Induction of Cephalosporinase and Penicillinase in
_Proteus_ Species. _Nature_ 201, 1032 (1964). https://doi.org/10.1038/2011032a0 Download citation * Issue Date: 07 March 1964 * DOI: https://doi.org/10.1038/2011032a0 SHARE THIS ARTICLE
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