N4-substituted n1-(3-dimethylaminopropyl)-piperazines : a new series of compounds active against trypanosoma cruzi infections in mice

N4-substituted n1-(3-dimethylaminopropyl)-piperazines : a new series of compounds active against trypanosoma cruzi infections in mice

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ABSTRACT RECENT reviews1–3 on the treatment of _Trypanosoma cruzi_ infections (Chagas's disease, South American trypanosomiasis) in man emphasize the lack of a satisfactory mode of therapy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS SYNTHESIS AND EVALUATION OF NITROCHROMENE DERIVATIVES AS POTENTIAL ANTILEISHMANIAL THERAPEUTICS THROUGH BIOLOGICAL AND COMPUTATIONAL STUDIES Article Open access 20 January 2025 SCREENING OF THE ANTILEISHMANIAL AND ANTIPLASMODIAL POTENTIAL OF SYNTHETIC 2-ARYLQUINOLINE ANALOGS Article Open access 16 October 2023 ANTIPLASMODIAL ACTIVITY, STRUCTURE–ACTIVITY RELATIONSHIP AND STUDIES ON THE ACTION OF NOVEL BENZIMIDAZOLE DERIVATIVES Article Open access 06 January 2023 REFERENCES * _World Health Org. Tech. Rep. Ser._ No. 202 (Geneva, 1960). * Kollert, W., _Clinical Excerpts_, 26, 89 (June, 1960) (Bayer, Leverkusen, Germany). Google Scholar  * Hawking, F., in _Experimental Chemotherapy_, edit. by Schnitzer, R. J., and Hawking, F., 1, 129 (Academic Press, New York, 1963). Book  Google Scholar  * Hewitt, R., Entwistle, J., and Gill, E., _J. Parasit._, 49, 22 (1963). Article  CAS  Google Scholar  * Pizzi, T., _Proc. Soc. Exp. Biol. and Med._, 78, 643 (1951). Article  CAS  Google Scholar  * Moraes, G. E. S., Faria, J. L., and Fernandes, J. F., _Rev. Inst. Med. trop. Sao Paulo_, 2, 147 (1960). CAS  Google Scholar  * Moon, A. P., and Coleman, J. F., _Bol. Chil. Parasit._, 17, 63 (1962). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Organic Chemical Research Section and Experimental Therapeutics Research Section, Lederle Laboratories Division, American Cyanamid Co., Pearl River, New York ANDREW S. TOMCUFCIK, REDGINAL I. HEWITT, PAUL F. FABIO, ARLENE M. HOFFMAN & JOSEPH ENTWISTLE Authors * ANDREW S. TOMCUFCIK View author publications You can also search for this author inPubMed Google Scholar * REDGINAL I. HEWITT View author publications You can also search for this author inPubMed Google Scholar * PAUL F. FABIO View author publications You can also search for this author inPubMed Google Scholar * ARLENE M. HOFFMAN View author publications You can also search for this author inPubMed Google Scholar * JOSEPH ENTWISTLE View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE TOMCUFCIK, A., HEWITT, R., FABIO, P. _et al._ _N_4-substituted _N_1-(3-Dimethylaminopropyl)-piperazines : a New Series of Compounds active against _Trypanosoma cruzi_ Infections in Mice. _Nature_ 205, 605–606 (1965). https://doi.org/10.1038/205605b0 Download citation * Issue Date: 06 February 1965 * DOI: https://doi.org/10.1038/205605b0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT RECENT reviews1–3 on the treatment of _Trypanosoma cruzi_ infections (Chagas's disease, South American trypanosomiasis) in man emphasize the lack of a satisfactory mode of


therapy. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to


this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy


now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer


support SIMILAR CONTENT BEING VIEWED BY OTHERS SYNTHESIS AND EVALUATION OF NITROCHROMENE DERIVATIVES AS POTENTIAL ANTILEISHMANIAL THERAPEUTICS THROUGH BIOLOGICAL AND COMPUTATIONAL STUDIES


Article Open access 20 January 2025 SCREENING OF THE ANTILEISHMANIAL AND ANTIPLASMODIAL POTENTIAL OF SYNTHETIC 2-ARYLQUINOLINE ANALOGS Article Open access 16 October 2023 ANTIPLASMODIAL


ACTIVITY, STRUCTURE–ACTIVITY RELATIONSHIP AND STUDIES ON THE ACTION OF NOVEL BENZIMIDAZOLE DERIVATIVES Article Open access 06 January 2023 REFERENCES * _World Health Org. Tech. Rep. Ser._


No. 202 (Geneva, 1960). * Kollert, W., _Clinical Excerpts_, 26, 89 (June, 1960) (Bayer, Leverkusen, Germany). Google Scholar  * Hawking, F., in _Experimental Chemotherapy_, edit. by


Schnitzer, R. J., and Hawking, F., 1, 129 (Academic Press, New York, 1963). Book  Google Scholar  * Hewitt, R., Entwistle, J., and Gill, E., _J. Parasit._, 49, 22 (1963). Article  CAS 


Google Scholar  * Pizzi, T., _Proc. Soc. Exp. Biol. and Med._, 78, 643 (1951). Article  CAS  Google Scholar  * Moraes, G. E. S., Faria, J. L., and Fernandes, J. F., _Rev. Inst. Med. trop.


Sao Paulo_, 2, 147 (1960). CAS  Google Scholar  * Moon, A. P., and Coleman, J. F., _Bol. Chil. Parasit._, 17, 63 (1962). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS


AND AFFILIATIONS * Organic Chemical Research Section and Experimental Therapeutics Research Section, Lederle Laboratories Division, American Cyanamid Co., Pearl River, New York ANDREW S.


TOMCUFCIK, REDGINAL I. HEWITT, PAUL F. FABIO, ARLENE M. HOFFMAN & JOSEPH ENTWISTLE Authors * ANDREW S. TOMCUFCIK View author publications You can also search for this author inPubMed 


Google Scholar * REDGINAL I. HEWITT View author publications You can also search for this author inPubMed Google Scholar * PAUL F. FABIO View author publications You can also search for this


author inPubMed Google Scholar * ARLENE M. HOFFMAN View author publications You can also search for this author inPubMed Google Scholar * JOSEPH ENTWISTLE View author publications You can


also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE TOMCUFCIK, A., HEWITT, R., FABIO, P. _et al._


_N_4-substituted _N_1-(3-Dimethylaminopropyl)-piperazines : a New Series of Compounds active against _Trypanosoma cruzi_ Infections in Mice. _Nature_ 205, 605–606 (1965).


https://doi.org/10.1038/205605b0 Download citation * Issue Date: 06 February 1965 * DOI: https://doi.org/10.1038/205605b0 SHARE THIS ARTICLE Anyone you share the following link with will be


able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing


initiative