Play all audios:
ABSTRACT GLUCOSE is the major substrate for the brain1,2, which utilizes a very high proportion of the bodily glucose requirement3. Whittam4 has calculated that about 40 per cent of the
energy produced from glucose metabolism in the brain is required for ion transport mechanisms important in maintaining the physiological function of the tissue. Over the past few years a
number of workers5–8 have demonstrated the high rate of incorporation of carbon-14 from glucose into brain amino-acids, particularly glutamic acid. It has been suggested6 that the
amino-acids have a special role as intermediates in the brain; that their formation and oxidation constitute a major pathway of glucose metabolism in the brain. However, the
characteristically high concentration of free glutamate in the brain, in contrast to other tissues, renders methods of investigations which are based on the labelling of the amino-acid
pools, rather than specific activity measurements on individual amino-acids isolated from the tissues, rather inconclusive. As has been suggested9, such results could be due to quantitative
differences in glycolysis and transamination reactions between the brain and the liver. Access through your institution Buy or subscribe This is a preview of subscription content, access via
your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this
article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in
* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TRACING THE LACTATE SHUTTLE TO THE MITOCHONDRIAL RETICULUM
Article Open access 08 September 2022 THE TWO-CELL MODEL OF GLUCOSE METABOLISM: A HYPOTHESIS OF SCHIZOPHRENIA Article Open access 05 January 2021 CIRCULATING METABOLITE HOMEOSTASIS ACHIEVED
THROUGH MASS ACTION Article 20 January 2022 REFERENCES * Himwich, H. E., _Brain Metabolism and Cerebral Disorders_ (Williams and Wilkins, Baltimore, 1951). Google Scholar * McIlwain, H.,
_Biochemistry and the Central Nervous System_, second ed. (Churchill, London, 1959). Google Scholar * Kety, S. S., _Metabolism of the Nervous System_, edit. by Richter, D., 223 (Pergamon
Press, 1957). Google Scholar * Whittam, R., _Nature_, 191, 603 (1961). Article ADS CAS Google Scholar * Roberts, R. B., Flexner, J. B., and Flexner, L. B., _J. Neurochem._, 4, 78
(1959). Article CAS Google Scholar * Vrba, R., _Nature_, 195, 663 (1962); Vrba, R., Gaitonde, M. K., and Richter, D., _J. Neurochem._, 9, 465 (1962). Article ADS CAS Google Scholar *
Chain, E. B., Cohen, M. M., and Pocchiari, F., _Proc. Roy. Soc._, B, 156, 163 (1962). Cohen, M. M., Simon, G. R., Berry, J. F., and Chain, E. B., _Biochem. J._, 84, 43P (1962). Article ADS
CAS Google Scholar * Geiger, A., _Physiol. Rev._, 38, I (1958). Geiger, A., Kawakita, Y., and Barkulis, S. S., _J. Neurochem._, 5, 323 (1960). Article Google Scholar * Haslam, R. J.,
and Krebs, H. A., _Biochem. J._, 88, 566 (1963). Article CAS Google Scholar * Krebs, H. A., Eggleston, L. V., _Biochem. J._, 44, 2 (1949). Tsukada, Y., Nagata, Y., Hirano, S., and
Matsutani, T., _J. Neurochem._, 10, 241 (1963). Article Google Scholar * Bachelard, H. S., Campbell, W. J., and McIlwain, H., _Biochem. J._, 84, 225 (1962). Article CAS Google Scholar *
Neish, W. J. P., _Rec. trav. chim._, 72, 105 (1953). Article CAS Google Scholar * Neish, W. J. P., _Meth. Biochem. Anal._, 5, 107 (1957). CAS Google Scholar * Bachelard, H. S., _Anal.
Biochem._ (in the press). * Bonting, S. L., _Arch. Biochem._, 58, 100 (1955). Article CAS Google Scholar * Patrick, S. J., _Canad. J. Biochem. and Physiol._, 41, 1163 (1963). Article CAS
Google Scholar * Gey, K. F., _Biochem. J._, 64, 145 (1956). Article CAS Google Scholar * Huggett, A. St. G., and Nixon, D. A., _Lancet_, ii, 368 (1957). Washko, M. E., and Rice, E. W.,
_Clin. Chem._, 7, 542 (1961). Article Google Scholar * Bruno, G. A., and Christian, J. E., _Anal. Chem._, 33, 1216 (1961). Article CAS Google Scholar Download references AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * Department of Biochemistry, Monash University, Clayton, Victoria, Australia H. S. BACHELARD Authors * H. S. BACHELARD View author publications You can
also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BACHELARD, H. Glucose Metabolism and α-Keto-acids in
Rat Brain and Liver _in vivo_. _Nature_ 205, 903–904 (1965). https://doi.org/10.1038/205903a0 Download citation * Issue Date: 27 February 1965 * DOI: https://doi.org/10.1038/205903a0 SHARE
THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to
clipboard Provided by the Springer Nature SharedIt content-sharing initiative