During the differentiation of erythrocytes some cells develop which contain a high concentration of haemoglobin and no cytoplasmic basophilia. Erythropoietin has the effect of increasing the

proportion of these cells in preparations of marrow. Two of the communications which follow discuss the effect on these cells of erythropoietin and of ageing and haemorrhage. The third

communication describes a factor in the serum of a polycythaemic calf which enhances the activity of erythropoietin.

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