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ABSTRACT THE fact that adrenaline can act differently in various organs has often been explained by assuming that there are different kinds of receptors1. A simpler explanation of these
differences in adrenaline action is that a single receptor, influenced in different ways by the different metabolic milieu in various organs, is sufficient to interpret all kinds of
adrenaline effects. If this assumption is correct, the well defined receptor quality of the adrenaline effect, as tested by the effectiveness of different types of receptor blocking agents,
can be transformed into another receptor quality in one organ, by changing its metabolic milieu. Access through your institution Buy or subscribe This is a preview of subscription content,
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SELECTIVITY FOR THE HUMAN Β1AR OVER Β2AR Article 22 October 2020 STRUCTURAL BASIS OF AGONIST SPECIFICITY OF Α1A-ADRENERGIC RECEPTOR Article Open access 10 August 2023 THE NEUROPEPTIDE
SUBSTANCE P REGULATES ALDOSTERONE SECRETION IN HUMAN ADRENALS Article Open access 29 May 2020 REFERENCES * Ahlquist, R., _J. Pharmaceut. Sci._, 55, 359 (1966). Article CAS Google Scholar
* Amsler, C., _Pflüger's Arch. Ges. Physiol._, 185, 86 (1920). Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Third Department of
Medicine, University Medical School, Budapest, Hungary G. KUNOS & M. SZENTIVÁNYI Authors * G. KUNOS View author publications You can also search for this author inPubMed Google Scholar *
M. SZENTIVÁNYI View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
KUNOS, G., SZENTIVÁNYI, M. Evidence favouring the Existence of a Single Adrenergic Receptor. _Nature_ 217, 1077–1078 (1968). https://doi.org/10.1038/2171077a0 Download citation * Received:
28 December 1967 * Revised: 07 February 1968 * Issue Date: 16 March 1968 * DOI: https://doi.org/10.1038/2171077a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to
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