Combined inhibition of influenza virus reproduction in cell culture using interferon and amantadine

Combined inhibition of influenza virus reproduction in cell culture using interferon and amantadine

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ABSTRACT AMANTADINE hydrochloride is the first synthetic ariti-influenza compound which has been successfully tested in human beings1,2. Results of an investigation showed that none of its derivatives was more effective than amantadine itself. Thus attempts to increase the antiviral prophylactic activity of amantadine and to reduce its dosage in order to diminish the toxicity3 are necessary. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MACROCYCLIC PEPTIDES EXHIBIT ANTIVIRAL EFFECTS AGAINST INFLUENZA VIRUS HA AND PREVENT PNEUMONIA IN ANIMAL MODELS Article Open access 11 May 2021 INHIBITORY EFFECTS OF APROTININ ON INFLUENZA A AND B VIRUSES IN VITRO AND IN VIVO Article Open access 03 May 2021 GINKGOLIC ACID INHIBITS ORTHOPNEUMO- AND METAPNEUMO- VIRUS INFECTIVITY Article Open access 08 April 2024 REFERENCES * Wood, T. R., _Ann. NY Acad. Sci._, 130, 419 (1965). Article  ADS  CAS  Google Scholar  * Stanley, E. D., Muldoon, L. W., Akers, L. W., and Jackson, G. G., _Ann. NY Acad. Sci._, 130, 44 (1965). Article  ADS  CAS  Google Scholar  * Sabin, A. B., _J. Amer. Med. Assoc._, 200, 943 (1967). Article  CAS  Google Scholar  * Lavrov, S. V., _Vop. Virus_ (in the press). * Davies, W. L., Grunert, R. R., Haff, R. F., McGahen, J. W., Neumayer, E. M., Paulshock, M., Walts, J. C., Wood, T. R., Hermann, E. C., and Hoffman, C. E., _Science_, 144, 862 (1964). Article  ADS  CAS  Google Scholar  * Marcus, P. J., and Salb, J. M., _Virology_, 30, 502 (1966). Article  CAS  Google Scholar  * Hallum, J., and Youngner, J., _J. Bact._, 92, 1047 (1966). CAS  PubMed  Google Scholar  * Soloviev, V. D., Bektemirov, T. A., Porubel, L. A., and Rapoport, R. I., _Vop. Virus_, 3, 311 (1966). Google Scholar  * Orlova, T. G., Mentkevich, L. M., Tatarinova, Yu. N., and Stakhanova, V. M., _Acta virol._, 11, 183 (1967). CAS  PubMed  Google Scholar  * Oxford, J. S., and Schild, G. C., _Brit. J. Exp. Pathol._, 48, 235 (1967). CAS  Google Scholar  * Smith, C. B., Purcell, R. H., and Chanock, R. M., _Amer. Rev. Resp. Dis._, 95, 689 (1967). CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * D. I. Ivanovsky Institute of Virology, Academy of Medical Sciences, Moscow S. V. LAVROV, E. I. EREMKINA, T. G. ORLOVA, G. A. GALEGOV, V. D. SOLOVIEV & V. M. ZHDANOV * N. F. Gamaleya Institute of Epidemiology and Microbiology, Moscow S. V. LAVROV, E. I. EREMKINA, T. G. ORLOVA, G. A. GALEGOV, V. D. SOLOVIEV & V. M. ZHDANOV Authors * S. V. LAVROV View author publications You can also search for this author inPubMed Google Scholar * E. I. EREMKINA View author publications You can also search for this author inPubMed Google Scholar * T. G. ORLOVA View author publications You can also search for this author inPubMed Google Scholar * G. A. GALEGOV View author publications You can also search for this author inPubMed Google Scholar * V. D. SOLOVIEV View author publications You can also search for this author inPubMed Google Scholar * V. M. ZHDANOV View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE LAVROV, S., EREMKINA, E., ORLOVA, T. _et al._ Combined Inhibition of Influenza Virus Reproduction in Cell Culture using Interferon and Amantadine. _Nature_ 217, 856–857 (1968). https://doi.org/10.1038/217856a0 Download citation * Received: 04 January 1968 * Issue Date: 02 March 1968 * DOI: https://doi.org/10.1038/217856a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT AMANTADINE hydrochloride is the first synthetic ariti-influenza compound which has been successfully tested in human beings1,2. Results of an investigation showed that none of its


derivatives was more effective than amantadine itself. Thus attempts to increase the antiviral prophylactic activity of amantadine and to reduce its dosage in order to diminish the toxicity3


are necessary. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution


Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full


article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs *


Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MACROCYCLIC PEPTIDES EXHIBIT ANTIVIRAL EFFECTS AGAINST INFLUENZA VIRUS HA AND PREVENT PNEUMONIA IN ANIMAL MODELS Article Open


access 11 May 2021 INHIBITORY EFFECTS OF APROTININ ON INFLUENZA A AND B VIRUSES IN VITRO AND IN VIVO Article Open access 03 May 2021 GINKGOLIC ACID INHIBITS ORTHOPNEUMO- AND METAPNEUMO-


VIRUS INFECTIVITY Article Open access 08 April 2024 REFERENCES * Wood, T. R., _Ann. NY Acad. Sci._, 130, 419 (1965). Article  ADS  CAS  Google Scholar  * Stanley, E. D., Muldoon, L. W.,


Akers, L. W., and Jackson, G. G., _Ann. NY Acad. Sci._, 130, 44 (1965). Article  ADS  CAS  Google Scholar  * Sabin, A. B., _J. Amer. Med. Assoc._, 200, 943 (1967). Article  CAS  Google


Scholar  * Lavrov, S. V., _Vop. Virus_ (in the press). * Davies, W. L., Grunert, R. R., Haff, R. F., McGahen, J. W., Neumayer, E. M., Paulshock, M., Walts, J. C., Wood, T. R., Hermann, E.


C., and Hoffman, C. E., _Science_, 144, 862 (1964). Article  ADS  CAS  Google Scholar  * Marcus, P. J., and Salb, J. M., _Virology_, 30, 502 (1966). Article  CAS  Google Scholar  * Hallum,


J., and Youngner, J., _J. Bact._, 92, 1047 (1966). CAS  PubMed  Google Scholar  * Soloviev, V. D., Bektemirov, T. A., Porubel, L. A., and Rapoport, R. I., _Vop. Virus_, 3, 311 (1966). Google


Scholar  * Orlova, T. G., Mentkevich, L. M., Tatarinova, Yu. N., and Stakhanova, V. M., _Acta virol._, 11, 183 (1967). CAS  PubMed  Google Scholar  * Oxford, J. S., and Schild, G. C.,


_Brit. J. Exp. Pathol._, 48, 235 (1967). CAS  Google Scholar  * Smith, C. B., Purcell, R. H., and Chanock, R. M., _Amer. Rev. Resp. Dis._, 95, 689 (1967). CAS  PubMed  Google Scholar 


Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * D. I. Ivanovsky Institute of Virology, Academy of Medical Sciences, Moscow S. V. LAVROV, E. I. EREMKINA, T. G. ORLOVA, G. A.


GALEGOV, V. D. SOLOVIEV & V. M. ZHDANOV * N. F. Gamaleya Institute of Epidemiology and Microbiology, Moscow S. V. LAVROV, E. I. EREMKINA, T. G. ORLOVA, G. A. GALEGOV, V. D. SOLOVIEV 


& V. M. ZHDANOV Authors * S. V. LAVROV View author publications You can also search for this author inPubMed Google Scholar * E. I. EREMKINA View author publications You can also search


for this author inPubMed Google Scholar * T. G. ORLOVA View author publications You can also search for this author inPubMed Google Scholar * G. A. GALEGOV View author publications You can


also search for this author inPubMed Google Scholar * V. D. SOLOVIEV View author publications You can also search for this author inPubMed Google Scholar * V. M. ZHDANOV View author


publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE LAVROV, S., EREMKINA, E.,


ORLOVA, T. _et al._ Combined Inhibition of Influenza Virus Reproduction in Cell Culture using Interferon and Amantadine. _Nature_ 217, 856–857 (1968). https://doi.org/10.1038/217856a0


Download citation * Received: 04 January 1968 * Issue Date: 02 March 1968 * DOI: https://doi.org/10.1038/217856a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to


read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing


initiative