ABSTRACT A decrease of 5-hydroxytryptamine in the brain after peripheral injection of hydrocortisone may be mediated through increased activity of tryptophan pyrrolase in the liver. This

suggests a relationship between biochemical changes in depressive disease. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Chemical Pathology, Institute of Neurology, Queen Square, London A. R. GREEN & G. CURZON Authors * A. R. GREEN View author

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PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE GREEN, A., CURZON, G. Decrease of 5-Hydroxytryptamine in the Brain provoked by Hydrocortisone and its Prevention by

Allopurinol. _Nature_ 220, 1095–1097 (1968). https://doi.org/10.1038/2201095a0 Download citation * Received: 30 July 1968 * Revised: 23 September 1968 * Issue Date: 14 December 1968 * DOI:

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