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ABSTRACT INJECTION of susceptible mice with a marine leukaemia virus markedly affects the immune response. A number of recent studies have demonstrated that mice infected with either Friend
or Rauscher leukaemia disease viruses have a marked immunological deficiency, as demonstrated by challenge immunization with a variety of antigens1–16. Many of these studies have been
concerned with individual antibody-forming cells and have shown that the number of haemolysin-producing cells in spleens of infected mice is markedly reduced6–14. Similarly, the number of
antibody-forming cells to _Escherichia coli_ is also suppressed in spleens of infected mice15,16. A direct relationship exists between the time of infection and the degree of such
immuno-depression. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution
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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS DYNAMIC CAUSAL MODELLING OF IMMUNE HETEROGENEITY Article Open access 31 May 2021 PRECLINICAL SAFETY AND IMMUNOGENICITY OF
_STREPTOCOCCUS PYOGENES_ (STREP A) PEPTIDE VACCINES Article Open access 08 January 2021 MODELING HUMAN ADAPTIVE IMMUNE RESPONSES WITH TONSIL ORGANOIDS Article 11 January 2021 REFERENCES *
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Cinader, B.) (C. Thomas, Springfield, Illinois, 1967). Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Microbiology, Albert Einstein Medical
Center and Temple University School of Medicine, Philadelphia, Pennsylvania, 19140 SHINJI HIRANO & HERMAN FRIEDMAN Authors * SHINJI HIRANO View author publications You can also search
for this author inPubMed Google Scholar * HERMAN FRIEDMAN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE HIRANO, S., FRIEDMAN, H. Effect of a Murine Leukaemia Virus on “Background” Antibody Plaque-forming Cells to Sheep Erythrocytes and _E. coli_ Antigen.
_Nature_ 224, 1316–1318 (1969). https://doi.org/10.1038/2241316a0 Download citation * Received: 31 March 1969 * Revised: 19 August 1969 * Issue Date: 27 December 1969 * DOI:
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