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Access through your institution Buy or subscribe Angiotropic lymphoma, also referred to as intravascular malignant lymphoma (IVL), is a rare non-Hodgkin's lymphoma characterized by
massive proliferation of neoplastic mononuclear cells within the lumina of venules, arterioles and capillaries.1 This entity was firstly described by Pfleger and Tappeiner in 1959 as an
endothelial neoplasm.2 Recent studies, however, unequivocally established the lymphoid nature of this rare intravascular lymphoma, based on immunohistochemical, ultrastructural and genetic
evidences.3 No atypical cells can be recognized on peripheral blood smear, since the cells reside on the lumina of the vessels. The obstruction of small blood vessels by lymphoma cells is
responsible for the clinical multiorgan ischemic manifestations. Neurological (multifocal cerebrovascular disease) and cutaneous manifestations are the most common reported,3 but also lungs,
heart, kidneys and genital female and male tracts are organs involved. We detail the first description of a case of IVL in a young adult with a clinical presentation of adult onset
Still's disease (AOSD). This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print
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local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Molina
A, Lombard C, Donlon T, Bangs CD, Dorfman RF . Immunohistochemical and cytogenetic studies indicate that malignant angioendotheliomatosis is a primary intravascular (angiotropic) lymphoma
_Cancer_ 1990 66: 474–479 Article CAS Google Scholar * Pfleger L, Tappeiner J . Zur Kenntnis der systemisierten endotheliomatose der cutanen blutegefasse (Reticulo-endotheliose)
_Hautarzt_ 1959 10: 359–363 CAS PubMed Google Scholar * Perniciaro C, Winkelmann RK, Daoud MS, Su WPD . Malignant angioendotheliomatosis is an angiotropic intravascular lymphoma.
Immunohistochemical, ultrastructural and molecular genetics studies _Am J Dermatopathol_ 1995 17: 242–248 Article CAS Google Scholar * Bottaro M, Berti E, Biondi A, Migone N, Crosti L .
Heteroduplex analysis of T-cell receptor γ gene rearrangements for diagnosis and monitoring of cutaneous T-cell lymphomas _Blood_ 1994 83: 3271–3278 Article CAS Google Scholar * Tateyama
H, Eimoto T, Tada T, Kamiya M, Fujiyoshi Y, Kajiura S . Congenital angiotropic lymphoma (intravascular lymphomatosis) of the T-cell type _Cancer_ 1991 67: 2131–2136 Article CAS Google
Scholar * Sangueza O, Hyder DM, Sangueza P . Intravascular lymphomatosis: report of an unusual case with T cell phenotype occurring in an adolescent male _J Cutan Pathol_ 1992 19: 226–231
Article CAS Google Scholar * Cabral DA, Tucker LB . Malignancies in children who initially present with rheumatic complaints _J Pediatr_ 1999 134: 53–57 Article CAS Google Scholar *
Trotta F, Dovigo L, Scapoli G, Cavazzini L, Castaldi GL . Immunoblastic malignant lymphoma in adult onset Still's disease _J Rheumatol_ 1993 20: 1788–1792 CAS PubMed Google Scholar *
Reichert LJM, Keuning JJ, van Beek M, van Rijthoven AWAM . Lymphnode histology simulating T cell lymphoma in adult-onse Still's disease _Ann Hematol_ 1992 65: 53–54 Article CAS
Google Scholar Download references ACKNOWLEDGEMENTS This work is partially supported by grants from MURST, Associazione Italiana Ricerca Cancro (AIRC) and Fondazione M Tettamanti (AB). We
thank Mrs Cinzia Guardamagna and Ornella Micheloni for their skillful technical support. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Anatomia ed Istologia Patologica e Citodiagnostica,
Monza, Italy G Isimbaldi & MG Valente * Centro Ricerca, ‘M Tettamanti’, Clinica Pediatrica, Università di Milano-Bicocca, Italy L Corral, S Songia & A Biondi * Medicina III,
Ospedale, S Gerardo, Monza, Italy S De Bianchi Authors * G Isimbaldi View author publications You can also search for this author inPubMed Google Scholar * L Corral View author publications
You can also search for this author inPubMed Google Scholar * S Songia View author publications You can also search for this author inPubMed Google Scholar * MG Valente View author
publications You can also search for this author inPubMed Google Scholar * S De Bianchi View author publications You can also search for this author inPubMed Google Scholar * A Biondi View
author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Isimbaldi, G., Corral,
L., Songia, S. _et al._ An unusual presentation of a case of T cell angiotropic (intravascular) lymphoma. _Leukemia_ 14, 2321–2322 (2000). https://doi.org/10.1038/sj.leu.2401941 Download
citation * Received: 08 February 2000 * Accepted: 25 July 2000 * Published: 20 December 2000 * Issue Date: 01 December 2000 * DOI: https://doi.org/10.1038/sj.leu.2401941 SHARE THIS ARTICLE
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