ABSTRACT _CEBPα_ mutations have been described in adult acute myeloid leukemia (AML) and conferred a favorable prognosis. However, _CEBPα_ mutation has not been reported in children. We

investigated 117 children with _de novo_ AML using DNA PCR assay followed by sequencing for each PCR product. _CEBPα_ mutations were detected in seven patients, four had FAB M2, two M1 and

one M4. _CEBPα_ mutations only occurred in patients with intermediate cytogenetics and not in 56 children with _AML1-ETO_, _CBFβ-MYH11_, _PML-RARα_ or _MLL_ rearrangements. Five patients had

mutations occurred in both N-terminal part and basic-leucine zipper (bZIP) domain, one had an N-terminal frameshift mutation and the remaining one had an inframe insertion in the bZIP

6% of childhood AML and most exhibited combined mutations in both N-terminal part and bZIP domain. Access through your institution Buy or subscribe This is a preview of subscription content,

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Scholar  Download references ACKNOWLEDGEMENTS This work is supported by Grant NSC 92-2314-B-182-026 from the National Science Council, Taiwan, and Grant MMH-E-93009 from Mackay Memorial

Hospital, Taipei, Taiwan. D-C Liang, I-J Hung, C-P Yang, H-C Liu, T-H Jaing and L-Y Wang are members of the Taiwan Pediatoric Oncology Group, Childhood Cancer Foundation, ROC (CCF) and thank

CCF for the continuous support to nationwide clinical trials. We thank Ms Meng-Chu Chou and Ms Yu-Shu Shih for their excellent technical assistance. AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Division of Pediatric Hematology-Oncology, Mackay Memorial Hospital, Taipei, Taiwan D -C Liang, H -C Liu & L -Y Wang * Division of Hematology-Oncology, Chang Gung Memorial

Hospital, Taipei, Taiwan L -Y Shih & C -F Huang * School of Medicine, Chang Gung University, Taoyuan, Taiwan L -Y Shih, I -J Hung & C -P Yang * Division of Pediatric

Hematology-Oncology, Chang Gung Children's Hospital, Linkou, Taiwan I -J Hung, C -P Yang &  T -H Jaing * Biostatistics Department, Childhood Cancer Foundation, Taipei, Taiwan W -H

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RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Liang, DC., Shih, LY., Huang, CF. _et al._ _CEBPα_ mutations in childhood acute myeloid leukemia.

_Leukemia_ 19, 410–414 (2005). https://doi.org/10.1038/sj.leu.2403608 Download citation * Received: 31 August 2004 * Accepted: 26 October 2004 * Published: 23 December 2004 * Issue Date: 01

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link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * childhood acute myeloid leukemia * _CEBPα_

mutations * cooperating mutations * _FLT3_ mutations * N-_ras_ mutations