ABSTRACT Multiple myeloma (MM) is an incurable B-cell malignancy characterized by accumulation of malignant plasma cells in bone marrow (BM) and recurrent or persistent infections. Toll-like

receptors (TLRs) are essential in the host defense against infections and today 10 human TLRs (TLR1-TLR10) and one TLR-homolog (RP105) have been characterized. B cells express several TLRs

(mainly TLR1, 6, 7, 9, 10 and RP105) and TLR-initiated responses in B cells include proliferation, anti-apoptosis effect and plasma cell (PC) differentiation. The present study was designed

to analyze the role of TLRs in MM. We show that frequent expressions of TLRs were detected in cell lines from MM patients (minimum six TLRs in each). In comparison, only few TLRs (mainly

to increased growth and survival of MM cells in MM patients. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

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Article Open access 18 July 2024 IDENTIFICATION AND VALIDATION OF ECTO-5' NUCLEOTIDASE AS AN IMMUNOTHERAPEUTIC TARGET IN MULTIPLE MYELOMA Article Open access 01 April 2022 JUST

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of Copenhagen, Denmark for technical assistance and Dr med. Anders Waage at St Olavs Hospital, Trondheim University Hospital, Norway for providing some of the patient material. This work was

supported by grants from the Central Norway Regional Health Authority, Norwegian University of Science and Technology, the Norwegian Cancer Society and the Norwegian Research Council.

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway J Bohnhorst, S H Moen, M

Fløttum, M Børset, T Espevik & A Sundan * Department of Hematology L54P4, Herlev Hospital, University of Copenhagen, Herlev, Denmark T Rasmussen & L Knudsen Authors * J Bohnhorst

View author publications You can also search for this author inPubMed Google Scholar * T Rasmussen View author publications You can also search for this author inPubMed Google Scholar * S H

Moen View author publications You can also search for this author inPubMed Google Scholar * M Fløttum View author publications You can also search for this author inPubMed Google Scholar * L

Knudsen View author publications You can also search for this author inPubMed Google Scholar * M Børset View author publications You can also search for this author inPubMed Google Scholar

* T Espevik View author publications You can also search for this author inPubMed Google Scholar * A Sundan View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHOR Correspondence to J Bohnhorst. ADDITIONAL INFORMATION Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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FIGURE LEGENDS (DOC 25 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bohnhorst, J., Rasmussen, T., Moen, S. _et al._ Toll-like receptors mediate

proliferation and survival of multiple myeloma cells. _Leukemia_ 20, 1138–1144 (2006). https://doi.org/10.1038/sj.leu.2404225 Download citation * Received: 06 September 2005 * Revised: 02

January 2006 * Accepted: 05 January 2006 * Published: 13 April 2006 * Issue Date: 01 June 2006 * DOI: https://doi.org/10.1038/sj.leu.2404225 SHARE THIS ARTICLE Anyone you share the following

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SharedIt content-sharing initiative KEYWORDS * Toll-like rfeceptor * multiple myeloma * plasma cells * proliferation * survival