ABSTRACT Multiple myeloma (MM) patients are strongly vulnerable to infections, which remain a major cause of death. During infection, human immune cells sense the presence of invading

pathogens through the Toll-like receptor family (TLR), which recognizes pathogen-associated molecular patterns (PAMP). We hypothesized that MM cells also could sense the presence of

microorganisms, thus promoting myeloma disease progression. Here, we report that human myeloma cell lines (HMCL) and primary myeloma cells express a broad range of TLR, and are sensitive to

the corresponding PAMP. Toll-like receptor 1, 7 and 9 are most frequently expressed by HMCL. The expression pattern of TLR does not correlate with the one of B cells, as TLR2 and 10 are lost

expression and function are not restricted to the cells of the immune system and could be of advantage for cancer cells. In MM, recurrent infections could promote tumor growth and favor

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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS JUST SCRATCHING THE SURFACE: NOVEL TREATMENT APPROACHES FOR MULTIPLE MYELOMA TARGETING CELL MEMBRANE PROTEINS

Article 03 July 2024 INFLAMMATION AND INFECTION IN PLASMA CELL DISORDERS: HOW PATHOGENS SHAPE THE FATE OF PATIENTS Article 02 February 2022 CONTEXT-DEPENDENT FUNCTIONS OF PATTERN RECOGNITION

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grants from La Ligue Contre le Cancer (équipe labélisée 2004), GJ was supported by the INSERM young investigator program. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * INSERM, U601, Nantes,

France G Jego, R Bataille, A Geffroy-Luseau, G Descamps & C Pellat-Deceunynck Authors * G Jego View author publications You can also search for this author inPubMed Google Scholar * R

Bataille View author publications You can also search for this author inPubMed Google Scholar * A Geffroy-Luseau View author publications You can also search for this author inPubMed Google

Scholar * G Descamps View author publications You can also search for this author inPubMed Google Scholar * C Pellat-Deceunynck View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to G Jego. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jego, G., Bataille, R.,

Geffroy-Luseau, A. _et al._ Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors. _Leukemia_ 20, 1130–1137 (2006).

https://doi.org/10.1038/sj.leu.2404226 Download citation * Received: 14 November 2005 * Revised: 03 January 2006 * Accepted: 11 January 2006 * Published: 20 April 2006 * Issue Date: 01 June

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is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * multiple myeloma * pathogens * Toll-like

receptors