ABSTRACT THE administration to rats of aflatoxin B1, a potent hepatotoxin and carcinogen, rapidly results in an inhibition of both hepatic RNA synthesis _in vivo_1 and Mg2+ and

Mn2+—(NH4)2SO4 stimulated RNA polymerase activities, assayed _in vitro_2,3. Previous work has demonstrated that the RNA polymerase enzyme, isolated from hepatic nucleic whose _in situ_

polymerase activity was inhibited by previous administration of aflatoxin B1 to the animals has an activity equal to that of enzyme isolated from control tissues3,4. The enzyme was

solubilized by incubating the nuclei in a low-salt medium, which predominantly extracts the nuclear polymerase enzyme. We have now carried our further experiments using the more vigorous

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BEING VIEWED BY OTHERS TOXICITY MECHANISMS OF AFLATOXIN M1 ASSISTED WITH MOLECULAR DOCKING AND THE TOXICITY-LIMITING ROLE OF TRANS-RESVERATROL Article Open access 25 August 2022

RADIOBIOLOGICAL SHOT NOISE EXPLAINS THREE MILE ISLAND BIODOSIMETRY INDICATING NEARLY 1,000 MSV EXPOSURES Article Open access 02 July 2020 STRUCTURAL INSIGHTS INTO NUCLEAR TRANSCRIPTION BY

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INFORMATION AUTHORS AND AFFILIATIONS * MRC Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, Carshalton, Surrey G. E. NEAL Authors * G. E. NEAL View author

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RNA Synthesis by Aflatoxin B1. _Nature_ 244, 432–435 (1973). https://doi.org/10.1038/244432a0 Download citation * Received: 26 February 1973 * Revised: 22 June 1973 * Issue Date: 17 August

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