Molecular basis of control of mitotic cell division in eukaryotes

Molecular basis of control of mitotic cell division in eukaryotes

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ABSTRACT MITOTIC division in _Physarum polycephalum_ is preceded by a marked increase in the phosphate content of very lysine-rich histone (Pp. F1) (ref. 1) due to phosphorylation of serine residues probably at specific points in the amino acid sequence2,3. The phosphate content of F1 histone has been measured by a number of groups under a variety of conditions in an attempt to understand the role of F1 phosphorylation and three facts have been established. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EVOLUTION OF OPPOSING REGULATORY INTERACTIONS UNDERLIES THE EMERGENCE OF EUKARYOTIC CELL CYCLE CHECKPOINTS Article Open access 27 May 2021 CORE CONTROL PRINCIPLES OF THE EUKARYOTIC CELL CYCLE Article Open access 08 June 2022 LIFE-CYCLE-COUPLED EVOLUTION OF MITOSIS IN CLOSE RELATIVES OF ANIMALS Article Open access 22 May 2024 REFERENCES * Bradbury, E. M., Inglis, R.J., Matthews, H. R., and Sarner, N., _Eur. J. Biochem._, 33, 131 (1973). Article  CAS  Google Scholar  * Langan, T.A., _Ann. N.Y. Acad. Sci._, 185, 166 (1971). Article  ADS  CAS  Google Scholar  * Dixon, G. H., Louie, A. J., McLeod, A. R., and Sing, M. T., _Trans. Biochem. Soc._ (in the press). * Panyim, S., and Chalkley, R., _Biochemistry_, 8, 3972 (1969). Article  CAS  Google Scholar  * Oliver, D., Balhorn, R., Granner, D., and Chalkley, R., _Biochemistry_, 11, 3921 (1972). Article  CAS  Google Scholar  * Balhorn, R., Chalkley, R., and Granner, D., _Biochemistry_, 11, 1094 (1972). Article  CAS  Google Scholar  * Balhorn, R., Riecke, O., and Chalkley, R., _Biochemistry_, 10, 3952 (1971). Article  CAS  Google Scholar  * Balhorn, R., Balhorn, M., Morris, H. P., and Chalkley, R., _Cancer Res._, 32, 1775 (1972). CAS  Google Scholar  * Stevely, W. S., and Stocken, L. A., _Biochem. J._, 110, 187 (1968). Article  CAS  Google Scholar  * Balhorn, R., Bordwell, J., Sellers, L., Granner, D., and Chalkley, R., _Biochem. biophys. Res. Commun._, 46, 1326 (1972). Article  CAS  Google Scholar  * Gurley, L. R., Walters, R. A., and Tobey, R. A., _Biochem. biophys. Res. Commun._, 50, 744 (1973). Article  CAS  Google Scholar  * Balhorn, R., Tanphaichitr, N., Chalkley, R., and Granner, D.K., _Biochemistry_, 12, 5146 (1973). Article  CAS  Google Scholar  * Marks, D.B., Paik, W. K., and Borun, T. W., _J. biol. Chem._, 248, 5600 (1973). Google Scholar  * Gurley, L. R., Walters, R. A., and Tobey, R. A., _J. Cell. Biol._ (in the press). * Lake, R. S., and Salzman, N. P., _Biochemistry_, 11, 4817 (1972). Article  CAS  Google Scholar  * Lake, R. S., _Nature new Biol._, 242, 145 (1973). Article  CAS  Google Scholar  * Bradbury, E. M., Inglis, R. J., and Matthews, H. R., _Nature_, 247, 257 (1974). Article  ADS  CAS  Google Scholar  * Lake, R. S., _J.Cell Biol._, 58, 317 (1973). Article  CAS  Google Scholar  * Oppenheim, A., and Katzir, N., _Expl Cell Res._, 68, 224 (1971). Article  CAS  Google Scholar  * Inglis, R. J., thesis, Univ. London (1974). * Bradbury, E. M., Carpenter, B. G., and Rattle, H. W. E., _Nature_, 241, 123 (1973). Article  ADS  CAS  Google Scholar  * Chin, B., Friedrich, P. D., and Bernstein, I. A., _J. gen. Microbiol._, 71, 93 (1972). Article  CAS  Google Scholar  * Sachsenmaier, W., Remy, U., and Plattner-Schoebel, R., _Expl Cell Res._, 73, 41 (1972). Article  CAS  Google Scholar  * Brewer, E. N., and Rusch, H. P., _Expl Cell Res._, 49, 79 (1968). Article  CAS  Google Scholar  * Mohberg, J., and Rusch, H. P., _Archs Biochem. Biophys._, 138, 418 (1970). Article  CAS  Google Scholar  * Rusch, H. P., _Adv. Cell Biol._, 1, 297 (1971). Google Scholar  * Guttes, E., and Guttes, S., in _Methods in Cell Physiology_ (edit. by Prescott, D. M.) 43 (Academic Press, New York, 1964). Google Scholar  * Daniel, J. W., and Baldwin, H. H., in _Methods in Cell Physiology_. (edit. by Prescott, D. M.) 9 (Academic Press, New York, 1964). Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Biophysics Laboratories, Portsmouth Polytechnic, Gun House, Hampshire Terrace, Portsmouth, UK E. M. BRADBURY, R. J. INGLIS & H. R. MATTHEWS * Department of Pharmacology, University of Colorado, School of Medicine, 4200 East 9th Avenue, Denver, Colorado, 80220 T. A. LANGAN Authors * E. M. BRADBURY View author publications You can also search for this author inPubMed Google Scholar * R. J. INGLIS View author publications You can also search for this author inPubMed Google Scholar * H. R. MATTHEWS View author publications You can also search for this author inPubMed Google Scholar * T. A. LANGAN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BRADBURY, E., INGLIS, R., MATTHEWS, H. _et al._ Molecular basis of control of mitotic cell division in eukaryotes. _Nature_ 249, 553–556 (1974). https://doi.org/10.1038/249553a0 Download citation * Received: 31 January 1974 * Revised: 18 February 1974 * Issue Date: 07 June 1974 * DOI: https://doi.org/10.1038/249553a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT MITOTIC division in _Physarum polycephalum_ is preceded by a marked increase in the phosphate content of very lysine-rich histone (Pp. F1) (ref. 1) due to phosphorylation of serine


residues probably at specific points in the amino acid sequence2,3. The phosphate content of F1 histone has been measured by a number of groups under a variety of conditions in an attempt to


understand the role of F1 phosphorylation and three facts have been established. Access through your institution Buy or subscribe This is a preview of subscription content, access via your


institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this


article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in


* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EVOLUTION OF OPPOSING REGULATORY INTERACTIONS UNDERLIES THE


EMERGENCE OF EUKARYOTIC CELL CYCLE CHECKPOINTS Article Open access 27 May 2021 CORE CONTROL PRINCIPLES OF THE EUKARYOTIC CELL CYCLE Article Open access 08 June 2022 LIFE-CYCLE-COUPLED


EVOLUTION OF MITOSIS IN CLOSE RELATIVES OF ANIMALS Article Open access 22 May 2024 REFERENCES * Bradbury, E. M., Inglis, R.J., Matthews, H. R., and Sarner, N., _Eur. J. Biochem._, 33, 131


(1973). Article  CAS  Google Scholar  * Langan, T.A., _Ann. N.Y. Acad. Sci._, 185, 166 (1971). Article  ADS  CAS  Google Scholar  * Dixon, G. H., Louie, A. J., McLeod, A. R., and Sing, M.


T., _Trans. Biochem. Soc._ (in the press). * Panyim, S., and Chalkley, R., _Biochemistry_, 8, 3972 (1969). Article  CAS  Google Scholar  * Oliver, D., Balhorn, R., Granner, D., and Chalkley,


R., _Biochemistry_, 11, 3921 (1972). Article  CAS  Google Scholar  * Balhorn, R., Chalkley, R., and Granner, D., _Biochemistry_, 11, 1094 (1972). Article  CAS  Google Scholar  * Balhorn,


R., Riecke, O., and Chalkley, R., _Biochemistry_, 10, 3952 (1971). Article  CAS  Google Scholar  * Balhorn, R., Balhorn, M., Morris, H. P., and Chalkley, R., _Cancer Res._, 32, 1775 (1972).


CAS  Google Scholar  * Stevely, W. S., and Stocken, L. A., _Biochem. J._, 110, 187 (1968). Article  CAS  Google Scholar  * Balhorn, R., Bordwell, J., Sellers, L., Granner, D., and Chalkley,


R., _Biochem. biophys. Res. Commun._, 46, 1326 (1972). Article  CAS  Google Scholar  * Gurley, L. R., Walters, R. A., and Tobey, R. A., _Biochem. biophys. Res. Commun._, 50, 744 (1973).


Article  CAS  Google Scholar  * Balhorn, R., Tanphaichitr, N., Chalkley, R., and Granner, D.K., _Biochemistry_, 12, 5146 (1973). Article  CAS  Google Scholar  * Marks, D.B., Paik, W. K., and


Borun, T. W., _J. biol. Chem._, 248, 5600 (1973). Google Scholar  * Gurley, L. R., Walters, R. A., and Tobey, R. A., _J. Cell. Biol._ (in the press). * Lake, R. S., and Salzman, N. P.,


_Biochemistry_, 11, 4817 (1972). Article  CAS  Google Scholar  * Lake, R. S., _Nature new Biol._, 242, 145 (1973). Article  CAS  Google Scholar  * Bradbury, E. M., Inglis, R. J., and


Matthews, H. R., _Nature_, 247, 257 (1974). Article  ADS  CAS  Google Scholar  * Lake, R. S., _J.Cell Biol._, 58, 317 (1973). Article  CAS  Google Scholar  * Oppenheim, A., and Katzir, N.,


_Expl Cell Res._, 68, 224 (1971). Article  CAS  Google Scholar  * Inglis, R. J., thesis, Univ. London (1974). * Bradbury, E. M., Carpenter, B. G., and Rattle, H. W. E., _Nature_, 241, 123


(1973). Article  ADS  CAS  Google Scholar  * Chin, B., Friedrich, P. D., and Bernstein, I. A., _J. gen. Microbiol._, 71, 93 (1972). Article  CAS  Google Scholar  * Sachsenmaier, W., Remy,


U., and Plattner-Schoebel, R., _Expl Cell Res._, 73, 41 (1972). Article  CAS  Google Scholar  * Brewer, E. N., and Rusch, H. P., _Expl Cell Res._, 49, 79 (1968). Article  CAS  Google Scholar


  * Mohberg, J., and Rusch, H. P., _Archs Biochem. Biophys._, 138, 418 (1970). Article  CAS  Google Scholar  * Rusch, H. P., _Adv. Cell Biol._, 1, 297 (1971). Google Scholar  * Guttes, E.,


and Guttes, S., in _Methods in Cell Physiology_ (edit. by Prescott, D. M.) 43 (Academic Press, New York, 1964). Google Scholar  * Daniel, J. W., and Baldwin, H. H., in _Methods in Cell


Physiology_. (edit. by Prescott, D. M.) 9 (Academic Press, New York, 1964). Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Biophysics Laboratories,


Portsmouth Polytechnic, Gun House, Hampshire Terrace, Portsmouth, UK E. M. BRADBURY, R. J. INGLIS & H. R. MATTHEWS * Department of Pharmacology, University of Colorado, School of


Medicine, 4200 East 9th Avenue, Denver, Colorado, 80220 T. A. LANGAN Authors * E. M. BRADBURY View author publications You can also search for this author inPubMed Google Scholar * R. J.


INGLIS View author publications You can also search for this author inPubMed Google Scholar * H. R. MATTHEWS View author publications You can also search for this author inPubMed Google


Scholar * T. A. LANGAN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS


ARTICLE BRADBURY, E., INGLIS, R., MATTHEWS, H. _et al._ Molecular basis of control of mitotic cell division in eukaryotes. _Nature_ 249, 553–556 (1974). https://doi.org/10.1038/249553a0


Download citation * Received: 31 January 1974 * Revised: 18 February 1974 * Issue Date: 07 June 1974 * DOI: https://doi.org/10.1038/249553a0 SHARE THIS ARTICLE Anyone you share the following


link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature


SharedIt content-sharing initiative