Role of myosin light chains in calcium regulation

Role of myosin light chains in calcium regulation

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ABSTRACT The evidence that rabbit DTNB light chains bind to ‘desensitised’ scallop myosin and restore calcium sensitivity, that is, they functionally replace the scallop EDTA light chain, may suggest that these light chains are involved in some type of calcium regulatory mechanism in rabbit myosin _in vivo_. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS REGULATION OF MYOSIN LIGHT-CHAIN PHOSPHORYLATION AND ITS ROLES IN CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Article 06 October 2021 THE REGULATORY LIGHT CHAIN MEDIATES INACTIVATION OF MYOSIN MOTORS DURING ACTIVE SHORTENING OF CARDIAC MUSCLE Article Open access 06 September 2021 THE FORCE OF THE MYOSIN MOTOR SETS COOPERATIVITY IN THIN FILAMENT ACTIVATION OF SKELETAL MUSCLES Article Open access 18 November 2022 REFERENCES * Ebashi, S., Endo, M., and Ohtsuki, I., _Q. Rev. Biophys._, 2, 351 (1969). Article  CAS  Google Scholar  * Kendrick-Jones, J., Lehman, W., and Szent-Györgyi, A. G., _J. molec. Biol._, 54, 313 (1970). Article  CAS  Google Scholar  * Lehman, W., Kendrick-Jones, J., and Szent-Györgyi, A. G., _Cold Spring Harbor Symp. quant. Biol._, 37, 319 (1972). Article  Google Scholar  * Szent-Györgyi, A. G., Szentkiralyi, E. M., and Kendrick-Jones, J., _J. molec. Biol._, 74, 179 (1973). Article  Google Scholar  * Locker, R. H., and Hagyard, C. J., _Archs Biochem. Biophys._, 122, 521 (1967). Article  CAS  Google Scholar  * Gaetjens, E., Bárány, K., Bailin, G., Oppenheimer, H., and Bárány, M., _Archs Biochem. Biophys._, 123, 82 (1968). Article  CAS  Google Scholar  * Gazith, J., Himmelfarb, S., and Harrington, W. F., _J. biol. Chem._, 245, 15 (1970). CAS  PubMed  Google Scholar  * Samaha, F. J., Guth, L., and Albers, R. W., _J. biol. Chem._, 245, 219 (1970). CAS  PubMed  Google Scholar  * Perrie, W. T., and Perry, S. V., _Biochem. J._, 119, 31 (1970). Article  CAS  Google Scholar  * Lowey, S., and Risby, D., _Nature_, 234, 81 (1971). Article  ADS  CAS  Google Scholar  * Sarkar, S., Sreter, F. A., and Gergely, J., _Proc. natn. Acad. Sci. U.S.A._, 68, 946 (1971). Article  ADS  CAS  Google Scholar  * Weeds, A. G., and Pope, B., _Nature_, 234, 85 (1971). Article  ADS  CAS  Google Scholar  * Kendrick-Jones, J., _Phil. Trans. R. Soc. Lond._, B 265, 183 (1973). Article  CAS  Google Scholar  * Weeds, A. G., and Lowey, S., _J. molec. Biol._, 61, 701 (1971). Article  CAS  Google Scholar  * Weeds, A. G., _Nature_, 223, 1362 (1969). Article  ADS  CAS  Google Scholar  * Weeds, A. G., and Frank, G., _Cold Spring Harbor Symp. quant. Biol._, 37, 9 (1972). Article  Google Scholar  * Stracher, A., _Biochem. biophys. Res. Commun._, 35, 519 (1969). Article  CAS  Google Scholar  * Dreizen, P., and Gershman, L. C., _Biochemistry_, 9, 1688 (1970). Article  CAS  Google Scholar  * Lowey, S., Slayter, H. S., Weeds, A. G., and Baker, H., _J. molec. Biol._, 42, 1 (1969). Article  CAS  Google Scholar  * Eisenberg, E., Zobel, C. R., and Moos, C., _Biochemistry_, 7, 3186 (1968). Article  CAS  Google Scholar  * Kendrick-Jones, J., Szentkiralyi, E. M., and Szent-Györgyi, A. G., _Cold Spring Harbor Symp. quant. Biol._, 37, 47 (1972). Article  Google Scholar  * Gershman, L. C., Stracher, A., and Dreizen, P., _J. biol. Chem._, 244, 2726 (1969). CAS  PubMed  Google Scholar  * Bray, D., and Brownlee, S. M., _Analyt. Biochem._, 55, 213 (1973). Article  CAS  Google Scholar  * Bremel, R. D., and Weber, A., _Nature_, 238, 97 (1972). CAS  Google Scholar  * Haselgrove, J. C., thesis, Univ. Cambridge. (1970). * Huxley, H. E., _Cold Spring Harbor Symp. quant. Biol._, 37, 361 (1972). Article  Google Scholar  * Weber, A., and Murray, J. M., _Physiol. Rev._, 53, 612 (1973). Article  CAS  Google Scholar  * Perrie, W. T., Smillie, L. B., and Perry, S. V., _Biochem. J._, 135, (1973). Article  CAS  Google Scholar  * Weber, K., and Osborn, M., _J. biol. Chem._, 244, 4406 (1969). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK J. Kendrick-Jones Authors * J. Kendrick-Jones View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kendrick-Jones, J. Role of myosin light chains in calcium regulation. _Nature_ 249, 631–634 (1974). https://doi.org/10.1038/249631a0 Download citation * Received: 17 January 1974 * Revised: 08 April 1974 * Issue Date: 14 June 1974 * DOI: https://doi.org/10.1038/249631a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. 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ABSTRACT The evidence that rabbit DTNB light chains bind to ‘desensitised’ scallop myosin and restore calcium sensitivity, that is, they functionally replace the scallop EDTA light chain,


may suggest that these light chains are involved in some type of calcium regulatory mechanism in rabbit myosin _in vivo_. Access through your institution Buy or subscribe This is a preview


of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only


$3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout


ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS REGULATION OF MYOSIN


LIGHT-CHAIN PHOSPHORYLATION AND ITS ROLES IN CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Article 06 October 2021 THE REGULATORY LIGHT CHAIN MEDIATES INACTIVATION OF MYOSIN MOTORS DURING


ACTIVE SHORTENING OF CARDIAC MUSCLE Article Open access 06 September 2021 THE FORCE OF THE MYOSIN MOTOR SETS COOPERATIVITY IN THIN FILAMENT ACTIVATION OF SKELETAL MUSCLES Article Open access


18 November 2022 REFERENCES * Ebashi, S., Endo, M., and Ohtsuki, I., _Q. Rev. Biophys._, 2, 351 (1969). Article  CAS  Google Scholar  * Kendrick-Jones, J., Lehman, W., and Szent-Györgyi, A.


G., _J. molec. Biol._, 54, 313 (1970). Article  CAS  Google Scholar  * Lehman, W., Kendrick-Jones, J., and Szent-Györgyi, A. G., _Cold Spring Harbor Symp. quant. Biol._, 37, 319 (1972).


Article  Google Scholar  * Szent-Györgyi, A. G., Szentkiralyi, E. M., and Kendrick-Jones, J., _J. molec. Biol._, 74, 179 (1973). Article  Google Scholar  * Locker, R. H., and Hagyard, C. J.,


_Archs Biochem. Biophys._, 122, 521 (1967). Article  CAS  Google Scholar  * Gaetjens, E., Bárány, K., Bailin, G., Oppenheimer, H., and Bárány, M., _Archs Biochem. Biophys._, 123, 82 (1968).


Article  CAS  Google Scholar  * Gazith, J., Himmelfarb, S., and Harrington, W. F., _J. biol. Chem._, 245, 15 (1970). CAS  PubMed  Google Scholar  * Samaha, F. J., Guth, L., and Albers, R.


W., _J. biol. Chem._, 245, 219 (1970). CAS  PubMed  Google Scholar  * Perrie, W. T., and Perry, S. V., _Biochem. J._, 119, 31 (1970). Article  CAS  Google Scholar  * Lowey, S., and Risby,


D., _Nature_, 234, 81 (1971). Article  ADS  CAS  Google Scholar  * Sarkar, S., Sreter, F. A., and Gergely, J., _Proc. natn. Acad. Sci. U.S.A._, 68, 946 (1971). Article  ADS  CAS  Google


Scholar  * Weeds, A. G., and Pope, B., _Nature_, 234, 85 (1971). Article  ADS  CAS  Google Scholar  * Kendrick-Jones, J., _Phil. Trans. R. Soc. Lond._, B 265, 183 (1973). Article  CAS 


Google Scholar  * Weeds, A. G., and Lowey, S., _J. molec. Biol._, 61, 701 (1971). Article  CAS  Google Scholar  * Weeds, A. G., _Nature_, 223, 1362 (1969). Article  ADS  CAS  Google Scholar


  * Weeds, A. G., and Frank, G., _Cold Spring Harbor Symp. quant. Biol._, 37, 9 (1972). Article  Google Scholar  * Stracher, A., _Biochem. biophys. Res. Commun._, 35, 519 (1969). Article 


CAS  Google Scholar  * Dreizen, P., and Gershman, L. C., _Biochemistry_, 9, 1688 (1970). Article  CAS  Google Scholar  * Lowey, S., Slayter, H. S., Weeds, A. G., and Baker, H., _J. molec.


Biol._, 42, 1 (1969). Article  CAS  Google Scholar  * Eisenberg, E., Zobel, C. R., and Moos, C., _Biochemistry_, 7, 3186 (1968). Article  CAS  Google Scholar  * Kendrick-Jones, J.,


Szentkiralyi, E. M., and Szent-Györgyi, A. G., _Cold Spring Harbor Symp. quant. Biol._, 37, 47 (1972). Article  Google Scholar  * Gershman, L. C., Stracher, A., and Dreizen, P., _J. biol.


Chem._, 244, 2726 (1969). CAS  PubMed  Google Scholar  * Bray, D., and Brownlee, S. M., _Analyt. Biochem._, 55, 213 (1973). Article  CAS  Google Scholar  * Bremel, R. D., and Weber, A.,


_Nature_, 238, 97 (1972). CAS  Google Scholar  * Haselgrove, J. C., thesis, Univ. Cambridge. (1970). * Huxley, H. E., _Cold Spring Harbor Symp. quant. Biol._, 37, 361 (1972). Article  Google


Scholar  * Weber, A., and Murray, J. M., _Physiol. Rev._, 53, 612 (1973). Article  CAS  Google Scholar  * Perrie, W. T., Smillie, L. B., and Perry, S. V., _Biochem. J._, 135, (1973).


Article  CAS  Google Scholar  * Weber, K., and Osborn, M., _J. biol. Chem._, 244, 4406 (1969). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * MRC


Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK J. Kendrick-Jones Authors * J. Kendrick-Jones View author publications You can also search for this author inPubMed Google


Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kendrick-Jones, J. Role of myosin light chains in calcium regulation. _Nature_ 249, 631–634


(1974). https://doi.org/10.1038/249631a0 Download citation * Received: 17 January 1974 * Revised: 08 April 1974 * Issue Date: 14 June 1974 * DOI: https://doi.org/10.1038/249631a0 SHARE THIS


ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard


Provided by the Springer Nature SharedIt content-sharing initiative