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ABSTRACT THE potency of anti-lymphocytic serum (ALS) in prolonging skin allografts has been well investigated. Four different routes of administration are being used: intravenous1,
intraperitoneal2, intramuscular3 and subcutaneous4. Every route has its own advantages and disadvantages from the immunological and clinical point of view and these have been discussed
elsewhere5,6. Oral application of ALS was never tried because it was assumed that intact proteins like gamma globulins are enzymatically metabolised before they pass through the intestinal
wall. But we shall demonstrate, that even oral application of ALS can prolong the survival time of skin allografts. Access through your institution Buy or subscribe This is a preview of
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J. Anat._, 121, 763 (1967). Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute for Surgical Research, Surgical University Clinic, 8000,
Munich, 2, Federal Republic of Germany J. SEIFERT, J. RING & W. BRENDEL Authors * J. SEIFERT View author publications You can also search for this author inPubMed Google Scholar * J.
RING View author publications You can also search for this author inPubMed Google Scholar * W. BRENDEL View author publications You can also search for this author inPubMed Google Scholar
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SEIFERT, J., RING, J. & BRENDEL, W. Prolongation of skin allografts after oral application of ALS in
rats. _Nature_ 249, 776 (1974). https://doi.org/10.1038/249776a0 Download citation * Received: 26 March 1974 * Issue Date: 21 June 1974 * DOI: https://doi.org/10.1038/249776a0 SHARE THIS
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