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ABSTRACT HISTOCOMPATIBILITY antigens carry the immunological determinants involved in tissue transplant rejection1. Recent evience has shown that papain-solubilised HL-A antigens are
composed of two polypeptide chains2,3. The smaller of the solubilised HL-A polypeptide chains has been shown4,5 to be identical to _β_2-microglobulin and it has also been shown that
_β_2-microglobulin is physically linked to the HL-A antigens on the cell surface6–9. These findings raised the question of whether the major transplantation antigens from other species are
composed of subunits. This communication shows that mouse H-2 alloantigens are linked to a small polypeptide chain which is homologous with human _β_2-microglobulin. Access through your
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Open access 12 April 2021 REFERENCES * Committee Report _Fedn Proc._, 31, 1087–1103 (1972). * Cresswell, P., Turner, M. J., and Strominger, J. L., _Proc natn. Acad. Sci. U.S.A._, 70,
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(1973). Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Institute of Medical Chemistry, Biomedical Centre and the Blood Centre, University of
Uppsala, Uppsala, Sweden LARS RASK, J. BERTIL LINDBLOM & PER A. PETERSON Authors * LARS RASK View author publications You can also search for this author inPubMed Google Scholar * J.
BERTIL LINDBLOM View author publications You can also search for this author inPubMed Google Scholar * PER A. PETERSON View author publications You can also search for this author inPubMed
Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE RASK, L., LINDBLOM, J. & PETERSON, P. Subunit structure of H-2 alloantigens. _Nature_
249, 833–834 (1974). https://doi.org/10.1038/249833a0 Download citation * Received: 28 December 1973 * Revised: 15 March 1974 * Issue Date: 28 June 1974 * DOI:
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