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ABSTRACT WE have described the antioxidant activity of calf thymus DNA on the oxidation of liposomal suspensions1; we now report the damaging consequences to the biological activity of
bacterial transforming DNA in such a system. Because DNA is associated with eukaryotic2 and bacterial cell membranes3, the DNA–membrane interaction described here may be relevant to several
pathological processes, including carcinogenesis4–7, ageing8–11 and oxygen-dependent, radiation-induced cell lethality10,11. In the presence of oxygen, the unsaturated fatty chains of
membrane phospholipid undergo autoxidation12. These autocatalytic free radical reactions, due to their chain nature, both amplify and propagate an initiating event occurring within the
membrane, during which time many highly reactive and potentially damaging chemical species are formed13. Access through your institution Buy or subscribe This is a preview of subscription
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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS BREAKING THE DNA BY SOFT X-RAYS IN THE
WATER WINDOW REVEALS THE SCAVENGING AND TEMPORAL BEHAVIOUR OF ·OH RADICALS Article Open access 18 November 2024 DIRECTLY IMAGING EMERGENCE OF PHASE SEPARATION IN PEROXIDIZED LIPID MEMBRANES
Article Open access 17 January 2023 PHOTOBIOCHEMICAL MECHANISMS OF BIOMOLECULES RELEVANT TO GERMICIDAL ULTRAVIOLET IRRADIATION AT 222 AND 254 NM Article Open access 29 October 2022
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_Collection Czechoslov. chem. Commun._ 38, 2167–2173 (1973). Article CAS Google Scholar Download references AUTHOR INFORMATION Author notes * DENNIS D. PIETRONIGRO Present address:
Department of Pharmacology, Yale University Medical School, New Haven, Ct, 06510 AUTHORS AND AFFILIATIONS * Department of Pathology, New York University Medical Center, New York, New York,
10016 DENNIS D. PIETRONIGRO, W. BARRIE G. JONES, KATHY KALTY & HARRY B. DEMOPOULOS Authors * DENNIS D. PIETRONIGRO View author publications You can also search for this author inPubMed
Google Scholar * W. BARRIE G. JONES View author publications You can also search for this author inPubMed Google Scholar * KATHY KALTY View author publications You can also search for this
author inPubMed Google Scholar * HARRY B. DEMOPOULOS View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE PIETRONIGRO, D., JONES, W., KALTY, K. _et al._ Interaction of DNA and liposomes as a model for membrane-mediated DNA damage. _Nature_ 267, 78–79 (1977).
https://doi.org/10.1038/267078a0 Download citation * Received: 13 September 1976 * Accepted: 01 March 1977 * Issue Date: 05 May 1977 * DOI: https://doi.org/10.1038/267078a0 SHARE THIS
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