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ABSTRACT CONSIDERATION of the facts of mammalian cell ‘transformation’ by viruses led us to the proposition that only a few genes or gene systems need necessarily be involved in the ageing
process1,2. These views accord in principle with conclusions derived from more recent analyses of the genetic basis for the increase in lifespan of hominid species in the last several
hundred thousand years, namely that mutations at no more than about 0.6% of the total genome could be responsible for the increase3,4. We describe here a study of ultimate lifespans (as
reflected by tenth deciles of survivorship) in congenic mice which suggests that the main histocompatibility complex (MHC) is one of the gene systems involved in the control of ageing.
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support SIMILAR CONTENT BEING VIEWED BY OTHERS INTERACTIONS BETWEEN IMMUNE CELL TYPES FACILITATE THE EVOLUTION OF IMMUNE TRAITS Article Open access 12 June 2024 EUROPEANS AND AMERICANS OF
EUROPEAN ORIGIN SHOW DIFFERENCES BETWEEN THEIR BIOLOGICAL PATHWAYS RELATED TO THE MAJOR HISTOCOMPATIBILITY COMPLEX Article Open access 18 September 2024 HUMAN IMMUNE DIVERSITY: FROM
EVOLUTION TO MODERNITY Article 18 November 2021 REFERENCES * Walford, R. L. _Gerontologia_ 18, 243–246 (1972). Article CAS Google Scholar * Walford, R. L. _Fed. Proc._ 33, 2020–2027
(1974). CAS PubMed Google Scholar * Cutler, R. G. _Proc. natn. Acad. Sci. U.S.A._ 72, 4664–4668 (1975). Article CAS ADS Google Scholar * Sacher, G. A. in _Antecedents of Man and
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Dimes, New York, in the press). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology, School of Medicine, University of California, Los Angeles,
California, 90024 GEORGE S. SMITH & ROY L. WALFORD Authors * GEORGE S. SMITH View author publications You can also search for this author inPubMed Google Scholar * ROY L. WALFORD View
author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SMITH, G., WALFORD, R.
Influence of the main histocompatibility complex on ageing in mice. _Nature_ 270, 727–729 (1977). https://doi.org/10.1038/270727a0 Download citation * Received: 21 July 1977 * Accepted: 24
July 1977 * Published: 01 December 1977 * Issue Date: 22 December 1977 * DOI: https://doi.org/10.1038/270727a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to
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