ABSTRACT Spontaneous thymic leukaemia in experimental mice is the result of a complex series of genetically controlled events1. An important step in this process involves the production by

thymocytes of recombinant polytropic retroviruses (MCF viruses)2,3. These leukaemogenic agents arise by recombination of genes from the _env_ regions of endogenous precursor viruses4,5.

Sequences in these regions encode the envelope glycoprotein gp70 (ref. 6). Thus far, each cloned isolate of recombinant virus from AKR and HRS/J mice has been found to possess unique

oligonucleotide sequences in its _env_ region, as well as clone-specific peptides in its gp70 (refs 7, 8). Therefore, the polytropic viruses of these leukaemia-susceptible mice are extremely

gp70, their hypothesis would predict extensive phenotypic diversity among spontaneous thymic leukaemias. In contrast, leukaemias induced by a particular leukaemogenic recombinant virus would

always have the same phenotype. Here we verify these predictions experimentally. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this

article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in

* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS LOSS OF THYMOCYTE COMPETITION UNDERLIES THE TUMOR SUPPRESSIVE

FUNCTIONS OF THE E2A TRANSCRIPTION FACTOR IN T-ALL Article 28 December 2023 GENETIC IN VIVO ENGINEERING OF HUMAN T LYMPHOCYTES IN MOUSE MODELS Article 12 April 2021 HUMAN THYMOMA-ASSOCIATED

MUTATION OF THE GTF2I TRANSCRIPTION FACTOR IMPAIRS THYMIC EPITHELIAL PROGENITOR DIFFERENTIATION IN MICE Article Open access 29 September 2022 REFERENCES * Schwartz, R. S., Datta, S. K.,

Hiai, H., Morrissey, P. J. & Waksal, S. D. in _Viruses in Naturally Occurring Cancers_ (Cold Spring Harbor Conf. on Cell Proliferation) Vol. 7 (1980). Google Scholar  * Hartley, J. W.,

Wolford, N. K., Old, L. J. & Rowe, W. P. _Proc. natn. Acad. Sci. U.S.A._ 74, 789–792 (1977). Article  ADS  CAS  Google Scholar  * Hiai, H., Morrissey, P., Khiroya, R. & Schwartz, R.

S. _Nature_ 270, 247–249 (1977). Article  ADS  CAS  Google Scholar  * Elder, J. H. _et al._ _Proc. natn. Acad. Sci. U.S.A._ 74, 4676–4680 (1977). Article  ADS  CAS  Google Scholar  *

Rommelaere, J., Faller, D. V. & Hopkins, N. in _Differentiation of Normal and Neoplastic Hematopoietic Cells_ (Cold Spring Harbor Conf. on Cell Proliferation) Vol. 5 (New York, 1978).

Google Scholar  * Rommelaere, J., Faller, D. V. & Hopkins, N. _Proc. natn. Acad. Sci. U.S.A._ 75, 495–499 (1978). Article  ADS  CAS  Google Scholar  * Cloyd, M. W., Hartley, J. W. &

Rowe, W. P. _J. exp. Med._ 151, 542–552 (1980). Article  CAS  Google Scholar  * Green, N. _et al._, _J. exp. Med._ 152, 249–264 (1980). Article  CAS  Google Scholar  * McGrath, M. &

Weissman, I. L. _Cell_ 17, 65–75 (1978). Article  Google Scholar  * Mathieson, B. J., Sharrow, S. O., Campbell, P. S. & Asofsky, R. _Nature_ 277, 478–480 (1979). Article  ADS  CAS 

Google Scholar  * Reisner, Y., Linker-Israeli, M. & Sharon, N. _Cell Immun._ 25, 129–134 (1976). Article  CAS  Google Scholar  * Zielinski, C. C., Datta, S. K. & Waksal, S. D.

_Immunogenetics_ (in the press). * Pepersack, L., Lee, J. C., McEwan, R. & Ihle, J. N. _J. Immun._ 124, 279–285 (1980). CAS  PubMed  Google Scholar  * Shih, T. Y., Wecks, M. O., Troxler,

D. H., Coffin, J. M. & Scolnick, E. M. _J. Virol._ 26, 71–83 (1978). CAS  PubMed  PubMed Central  Google Scholar  * Mathieson, B. J., Campbell, P. S., Potter, J. & Asofsky, R. _J.

exp. Med._ 147, 1267–1279 (1978). Article  CAS  Google Scholar  * Krammer, P. J., Citronbaum, R., Read, S. E., Forni, L. & Lang, R. _Cell. Immun._ 21, 97–111 (1976). Article  CAS  Google

Scholar  * Zielinski, C. C., Waters, D. L., Datta, S. K. & Waksal, S. D. _Cell. Immun._ (in the press). * Elder, J. H., Gautsch, J. W., Jensen, F. C. & Lerner, R. A. _J. natn.

Cancer Inst._ 61, 625–638 (1978). CAS  Google Scholar  * Schwartz, R. S. & Beldotti, L. _Science_ 149, 1511–1513 (1965). Article  ADS  CAS  Google Scholar  * Roussel, M. _et al._

_Nature_ 281, 452–455 (1979). Article  ADS  CAS  Google Scholar  * Reinherz, E. L. & Schlossman, S. F. _Cell_ 19, 821–827 (1980). Article  CAS  Google Scholar  Download references AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Departments of Medicine and Pathology and the Tufts Cancer Research Center, Tufts University School of Medicine, Boston, Massachusetts, 02111

Christoph C. Zielinski, Samuel D. Waksal, Laurence D. Tempelis, Raman H. Khiroya & Robert S. Schwartz Authors * Christoph C. Zielinski View author publications You can also search for

this author inPubMed Google Scholar * Samuel D. Waksal View author publications You can also search for this author inPubMed Google Scholar * Laurence D. Tempelis View author publications

You can also search for this author inPubMed Google Scholar * Raman H. Khiroya View author publications You can also search for this author inPubMed Google Scholar * Robert S. Schwartz View

author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zielinski, C., Waksal,

S., Tempelis, L. _et al._ Surface phenotypes in T-cell leukaemia are determined by oncogenic retroviruses. _Nature_ 288, 489–491 (1980). https://doi.org/10.1038/288489a0 Download citation *

Received: 15 July 1980 * Accepted: 01 October 1980 * Issue Date: 04 December 1980 * DOI: https://doi.org/10.1038/288489a0 SHARE THIS ARTICLE Anyone you share the following link with will be

able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing

initiative