ABSTRACT The study of the extent and basis of gene-enzyme variation has long been a principal concern of population genetics. Numerous surveys have indicated considerable amounts of genetic

variation detectable in natural populations, with few exceptions1–14. The variances of average heterozygosities (_H_) between species and among populations within species are large,

prompting Lewontin to emphasize the importance of large gene sample sizes7 and Selander to encourage analysis of variation of homologous gene-enzyme systems when making species comparisons8.

We present here a comparative genetic analysis of electrophoretic variation at 57 homologous biochemical loci of cats, mice and men. The distribution of polymorphism among the sampled loci

hypotheses for classifying polymorphic and monomorphic loci in terms of physiological and physical enzyme characteristics have been re-examined. Access through your institution Buy or

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GENETICS OF RANDOMLY BRED CATS SUPPORT THE CRADLE OF CAT DOMESTICATION BEING IN THE NEAR EAST Article Open access 01 November 2022 POPULATION GENETIC STRUCTURE OF EUROPEAN WILDCATS

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21, 97–103 (1968). Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Viral Carcinogenesis, National Cancer Institute, National

Institute of Health—Frederick Cancer Research Center, Frederick, Maryland, 21701 Stephen J. O'Brien * Biometry Branch, National Cancer Institute, National Institutes of Health,

Bethesda, Maryland, 20205 Mitchell H. Gail & David L. Levin Authors * Stephen J. O'Brien View author publications You can also search for this author inPubMed Google Scholar *

Mitchell H. Gail View author publications You can also search for this author inPubMed Google Scholar * David L. Levin View author publications You can also search for this author inPubMed 

Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE O'Brien, S., Gail, M. & Levin, D. Correlative genetic variation in natural

populations of cats, mice and men. _Nature_ 288, 580–583 (1980). https://doi.org/10.1038/288580a0 Download citation * Received: 05 May 1980 * Accepted: 27 October 1980 * Issue Date: 11

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