ABSTRACT A specific protein of molecular weight (MW) ∼55,000 (55K) was found recently by immunoprecipitation in all SV40 virus-transformed mammalian cells1–8, in addition to the SV40 large T

antigen (∼94K) and small t antigen (∼17K), which are the only proteins coded by the ‘early half’ of the SV40 genome. The 55K protein is encoded by cellular DNA; its peptide pattern is

different from that of the SV40 antigens and it is species specific in mouse, rat, hamster, monkey and human SV40-transformed (or infected) cells6–9. A 55K protein with a similar peptide

pattern was found in mouse embryonal carcinoma cells not exposed to SV404,5. Similar proteins were reported in mouse sarcomas and leukaemias induced by a great variety of aetiological agents

indistinguishable from that of the SV40-induced protein. We also show by comparing closely related cell families that spontaneously transformed highly tumorigenic mouse cells do not possess

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS MOLECULAR ARCHITECTURE AND CONSERVATION OF AN IMMATURE HUMAN ENDOGENOUS RETROVIRUS Article Open access 24 August 2023 MYC

ONCOGENE ELICITS TUMORIGENESIS ASSOCIATED WITH EMBRYONIC, RIBOSOMAL BIOGENESIS, AND TISSUE-LINEAGE DEDIFFERENTIATION GENE EXPRESSION CHANGES Article 07 October 2022 IDENTIFICATION OF A

HERPES SIMPLEX VIRUS 1 GENE ENCODING NEUROVIRULENCE FACTOR BY CHEMICAL PROTEOMICS Article Open access 29 September 2020 REFERENCES * Chang, C., Simmons, D. T., Martin, M. A. & Mora, P.

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Health, National Cancer Institute, Bethesda, Maryland, 20205 Peter T. Mora, K. Chandrasekaran & Vivian W. McFarland Authors * Peter T. Mora View author publications You can also search

for this author inPubMed Google Scholar * K. Chandrasekaran View author publications You can also search for this author inPubMed Google Scholar * Vivian W. McFarland View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mora, P., Chandrasekaran, K.

& McFarland, V. An embryo protein induced by SV40 virus transformation of mouse cells. _Nature_ 288, 722–724 (1980). https://doi.org/10.1038/288722a0 Download citation * Received: 18

June 1980 * Accepted: 06 November 1980 * Issue Date: 18 December 1980 * DOI: https://doi.org/10.1038/288722a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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