Brain catecholamines in schizophrenia — a good case for noradrenaline

Brain catecholamines in schizophrenia — a good case for noradrenaline

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Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Matthysse, S.W. & Kety, S.S. (eds) _Catecholamines and Schizophrenia_ (Pergamon, Oxford, 1975). * Iversen, L.L., Iversen, S.D. & Snyder, S.H. (eds) _Hand-book of Psychopharmacology_ Vol. 10 (Plenum, New York, 1978). * Seeman, P. _Pharmac. Rev._ 32, 229 (1980). CAS  Google Scholar  * Ahmed, A. & Marshall, P.B. _Br. J. Pharmac._ 18, 247 (1962). CAS  Google Scholar  * Duviosin, R.C. _Arch. Neurol._ 17, 124 (19167). * Hornykiewiez, O. in _The Neurobioiogy of Dopamine_ (eds Horn, A.S., Korf, J. & Westerink, B.H.C.) 633 (Academic, New York, 1979). Google Scholar  * Mackay, A.V.P. _et al._ _Lancet_ II, 915 (1980). Article  Google Scholar  * Reynolds, G.P., Reynolds, L.M., Riederer, P., Jellinger, K. & Gabriel, E. _Lancet_ II, 1251 (1980). Article  Google Scholar  * Iversen, S.D. in _Handbook of Psychopharmacology_ Vol. 8 (eds Iversen, L.L., Iversen, S.D. & Snyder, S.H.) 333 (Plenum, New York, 1977). Book  Google Scholar  * Chouinard, G. & Jones, B.D. _Am. J. Psychiat._ 137, 16 (1980). Article  CAS  Google Scholar  * Marsden, C.D. Personal communication. * Moore, R.Y. & Bloom, F.E. _A. Rev. Neurosci._ 2, 133 (1979). Article  Google Scholar  * Farley, I.J., Price, K.S. & Hornykiewiez, O. in _Limbic Mechanisms_ (eds Livingston, K.E. & Hornykiewicz, O.) 333 (Plenum, New York, 1978). Book  Google Scholar  * Kety, S. in _The Neurosciences_, 2nd Study Program (ed. Schmitt, P.O.) 324 (The Rockefeller University Press, New York, 1970). Google Scholar  * Laverty, R. _Prog. Neurobiol._ 3, 31 (1974). Article  Google Scholar  * Iversen, L.L., Iversen, S.D. & Snyder, S.H. (eds) _Hand-book of Psychopharmacology_ Vol. 8 (PlenumNew York, 1977). * Bolme, P., Fuxe, K. & Lindbrink, P. _Res. Commun. chem. Path. Pharmac._ 4, 657 (1972). CAS  Google Scholar  * Freedman, R., Hoffer, B.J., Puro, D. & Woodward, D.J. _Br. J. Pharmac._ 57, 603 (1976). Article  CAS  Google Scholar  * Segal, M. & Bloom, F.E. _Brain Res._ 107, 513 (1976). Article  CAS  Google Scholar  * Peroutka, S.J., U'Prichard, D.C., Greenberg, D.A. & Snyder, S.H. _Neuropharmacology_ 16, 549 (1977). Article  CAS  Google Scholar  * Blumberg, J.B., Vetulani, J., Stawarz, R.J. & Sulser, F. _Eur. J. Pharmac._ 37, 357 (1976). Article  CAS  Google Scholar  * Keller, H.H., Bartholini, G. & Pletscher, A. _Eur. J. Pharmac._ 23, 183 (1973). Article  CAS  Google Scholar  * Marwaha, J., Hoffer, B.J., Geller, H.M. & Freedman, R. _Psychopharmacology_ 73, 126 (1981). Article  CAS  Google Scholar  * Kornetsky, C. & Markowitz, R. in _Model Systems in Biological Psychiatry_ (eds Ingle, D.J. & Schein, H.) 26 (MIT Press, 1975). Google Scholar  * Kornetsky, C. & Mirsky, A.F. _Psychopharmacologia_ 8, 309 (1966). Article  CAS  Google Scholar  * Kornetsky, C. & Eliasson, M. _Science_ 165, 1273 (1969). Article  ADS  CAS  Google Scholar  * Longo, V.G. _Neuropharmacology and Behaviour_ (Freeman, San Francisco, 1972). Google Scholar  * Bradley, P.B. & Key, B.J. _Electroenceph. clin. Neurophysiol._ 10, 560 (1968). Google Scholar  * Boakes, J., Bradley, P.B. & Candy, J.M. _Br. J. Pharmac._ 45, 391 (1972). Article  CAS  Google Scholar  * Freedman, R. _Biol. Psychiat._ 12, 181 (1977). CAS  PubMed  Google Scholar  * Farley, I.J. _et al._ _Science_ 200, 456 (1978). Article  ADS  CAS  Google Scholar  * Kleinman, J.E. _et al._ _3rd Wld Congr. of Biological Psychiatry, Abstr. S195_, Stockholm (1981). Google Scholar  * Carlsson, A. in _Catecholamines: Basic and Clinical Frontiers_ Vol. 1 (eds Usdin, E., Kopin, l.J. & Barchas, J.) 4 (Pergamon, Oxford, 1979). Book  Google Scholar  * Lake, C.R. _et al._ _Science_ 207, 331 (1980). Article  ADS  CAS  Google Scholar  * Gomes, U.C.R., Shanley, B.C., Potgieter, L., Roux, J.T. _Br. J. Psychiat._ 137, 346 (1980). Article  CAS  Google Scholar  * Sternberg, D.E. _et al._ _Am. J. Psychiat._ 138, 1045 (1981). Article  CAS  Google Scholar  * Coyle, J.T. _Int. Rev. Neurobiol._ 20, 65 (1977). Article  CAS  Google Scholar  * Moore, R.Y., Björklund, A. & Stenevi, U. _Brain Res._ 33, 13 (1971). Article  CAS  Google Scholar  * Stenevi, U., Björklund, A. & Moore, R.Y. _Expl Neurol._ 35, 290 (1972). Article  CAS  Google Scholar  * Johnstone, E.C., Frith, C.D., Crow, T.J., Husband, J. & Kreel, L. _Lancet_ II, 924 (1976). Article  Google Scholar  * Weinberger, D.R., Torrey, E.F., Neophytides, A.N. & Wyatt, R.J. _Arch. gen. Psychiat._ 36, 735 (1979). Article  CAS  Google Scholar  * Okasha, A. & Madkour, O. _Acta psychiat. scand._ 65, 29 (1982). Article  CAS  Google Scholar  * Lloyd, K.G. in _Essays in Neurochemistry and Neuropharmacology_ (eds Youdim, M.B.H., Lovenberg, W., Sharman, D.F. & Lagnado, J.R.) 129 (Wiley, Chichester, 1979). Google Scholar  * Antelman, S.M., Caggiula, A.R. _Science_ 195, 646 (1977). Article  ADS  CAS  Google Scholar  * Tassin, J.P. _et al._ _Nature_ 295, 696 (1982). Article  ADS  CAS  Google Scholar  * Yorkston, N.J., Zaki, S.A., Weller, M.P., Gruzelier, J.H. & Hirsch, S.R. _Acta psychiat. scand._ 63, 13 (1981). Article  CAS  Google Scholar  * Peet, M., Middlemiss, D.An. & Yates, R.A. _Br. J. Psychiat._ 138, 112 (1981). Article  Google Scholar  * Freedman, R. _et al._ _Acta psychiat. scand._ 65, 35 (1982). Article  CAS  Google Scholar  * Adler, L.E., Bell, J., Kirch, D., Friedrich, E. & Freedman, R. _Am. J. Psychiat._ 139, 110 (1982). Article  CAS  Google Scholar  * Langer, S.Z. _Pharmac. Rev._ 102, 337 (1981). Google Scholar  * Holmberg, G. & Gershon, S. _Psychopharmacologia_ 2, 93 (1961). Article  CAS  Google Scholar  * Feldman, P.E. _J. clin. exp. Psychopath_, 20, 235 (1959). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Professor of Biochemical Pharmacology at the Faculty of Medicine of the University of Vienna, A-1090, Borschkeg, 8A, Austria Oleh Hornykiewicz Authors * Oleh Hornykiewicz View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hornykiewicz, O. Brain catecholamines in schizophrenia — a good case for noradrenaline. _Nature_ 299, 484–486 (1982). https://doi.org/10.1038/299484a0 Download citation * Issue Date: 07 October 1982 * DOI: https://doi.org/10.1038/299484a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this


journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now


Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer


support REFERENCES * Matthysse, S.W. & Kety, S.S. (eds) _Catecholamines and Schizophrenia_ (Pergamon, Oxford, 1975). * Iversen, L.L., Iversen, S.D. & Snyder, S.H. (eds) _Hand-book of


Psychopharmacology_ Vol. 10 (Plenum, New York, 1978). * Seeman, P. _Pharmac. Rev._ 32, 229 (1980). CAS  Google Scholar  * Ahmed, A. & Marshall, P.B. _Br. J. Pharmac._ 18, 247 (1962).


CAS  Google Scholar  * Duviosin, R.C. _Arch. Neurol._ 17, 124 (19167). * Hornykiewiez, O. in _The Neurobioiogy of Dopamine_ (eds Horn, A.S., Korf, J. & Westerink, B.H.C.) 633 (Academic,


New York, 1979). Google Scholar  * Mackay, A.V.P. _et al._ _Lancet_ II, 915 (1980). Article  Google Scholar  * Reynolds, G.P., Reynolds, L.M., Riederer, P., Jellinger, K. & Gabriel, E.


_Lancet_ II, 1251 (1980). Article  Google Scholar  * Iversen, S.D. in _Handbook of Psychopharmacology_ Vol. 8 (eds Iversen, L.L., Iversen, S.D. & Snyder, S.H.) 333 (Plenum, New York,


1977). Book  Google Scholar  * Chouinard, G. & Jones, B.D. _Am. J. Psychiat._ 137, 16 (1980). Article  CAS  Google Scholar  * Marsden, C.D. Personal communication. * Moore, R.Y. &


Bloom, F.E. _A. Rev. Neurosci._ 2, 133 (1979). Article  Google Scholar  * Farley, I.J., Price, K.S. & Hornykiewiez, O. in _Limbic Mechanisms_ (eds Livingston, K.E. & Hornykiewicz,


O.) 333 (Plenum, New York, 1978). Book  Google Scholar  * Kety, S. in _The Neurosciences_, 2nd Study Program (ed. Schmitt, P.O.) 324 (The Rockefeller University Press, New York, 1970).


Google Scholar  * Laverty, R. _Prog. Neurobiol._ 3, 31 (1974). Article  Google Scholar  * Iversen, L.L., Iversen, S.D. & Snyder, S.H. (eds) _Hand-book of Psychopharmacology_ Vol. 8


(PlenumNew York, 1977). * Bolme, P., Fuxe, K. & Lindbrink, P. _Res. Commun. chem. Path. Pharmac._ 4, 657 (1972). CAS  Google Scholar  * Freedman, R., Hoffer, B.J., Puro, D. &


Woodward, D.J. _Br. J. Pharmac._ 57, 603 (1976). Article  CAS  Google Scholar  * Segal, M. & Bloom, F.E. _Brain Res._ 107, 513 (1976). Article  CAS  Google Scholar  * Peroutka, S.J.,


U'Prichard, D.C., Greenberg, D.A. & Snyder, S.H. _Neuropharmacology_ 16, 549 (1977). Article  CAS  Google Scholar  * Blumberg, J.B., Vetulani, J., Stawarz, R.J. & Sulser, F.


_Eur. J. Pharmac._ 37, 357 (1976). Article  CAS  Google Scholar  * Keller, H.H., Bartholini, G. & Pletscher, A. _Eur. J. Pharmac._ 23, 183 (1973). Article  CAS  Google Scholar  *


Marwaha, J., Hoffer, B.J., Geller, H.M. & Freedman, R. _Psychopharmacology_ 73, 126 (1981). Article  CAS  Google Scholar  * Kornetsky, C. & Markowitz, R. in _Model Systems in


Biological Psychiatry_ (eds Ingle, D.J. & Schein, H.) 26 (MIT Press, 1975). Google Scholar  * Kornetsky, C. & Mirsky, A.F. _Psychopharmacologia_ 8, 309 (1966). Article  CAS  Google


Scholar  * Kornetsky, C. & Eliasson, M. _Science_ 165, 1273 (1969). Article  ADS  CAS  Google Scholar  * Longo, V.G. _Neuropharmacology and Behaviour_ (Freeman, San Francisco, 1972).


Google Scholar  * Bradley, P.B. & Key, B.J. _Electroenceph. clin. Neurophysiol._ 10, 560 (1968). Google Scholar  * Boakes, J., Bradley, P.B. & Candy, J.M. _Br. J. Pharmac._ 45, 391


(1972). Article  CAS  Google Scholar  * Freedman, R. _Biol. Psychiat._ 12, 181 (1977). CAS  PubMed  Google Scholar  * Farley, I.J. _et al._ _Science_ 200, 456 (1978). Article  ADS  CAS 


Google Scholar  * Kleinman, J.E. _et al._ _3rd Wld Congr. of Biological Psychiatry, Abstr. S195_, Stockholm (1981). Google Scholar  * Carlsson, A. in _Catecholamines: Basic and Clinical


Frontiers_ Vol. 1 (eds Usdin, E., Kopin, l.J. & Barchas, J.) 4 (Pergamon, Oxford, 1979). Book  Google Scholar  * Lake, C.R. _et al._ _Science_ 207, 331 (1980). Article  ADS  CAS  Google


Scholar  * Gomes, U.C.R., Shanley, B.C., Potgieter, L., Roux, J.T. _Br. J. Psychiat._ 137, 346 (1980). Article  CAS  Google Scholar  * Sternberg, D.E. _et al._ _Am. J. Psychiat._ 138, 1045


(1981). Article  CAS  Google Scholar  * Coyle, J.T. _Int. Rev. Neurobiol._ 20, 65 (1977). Article  CAS  Google Scholar  * Moore, R.Y., Björklund, A. & Stenevi, U. _Brain Res._ 33, 13


(1971). Article  CAS  Google Scholar  * Stenevi, U., Björklund, A. & Moore, R.Y. _Expl Neurol._ 35, 290 (1972). Article  CAS  Google Scholar  * Johnstone, E.C., Frith, C.D., Crow, T.J.,


Husband, J. & Kreel, L. _Lancet_ II, 924 (1976). Article  Google Scholar  * Weinberger, D.R., Torrey, E.F., Neophytides, A.N. & Wyatt, R.J. _Arch. gen. Psychiat._ 36, 735 (1979).


Article  CAS  Google Scholar  * Okasha, A. & Madkour, O. _Acta psychiat. scand._ 65, 29 (1982). Article  CAS  Google Scholar  * Lloyd, K.G. in _Essays in Neurochemistry and


Neuropharmacology_ (eds Youdim, M.B.H., Lovenberg, W., Sharman, D.F. & Lagnado, J.R.) 129 (Wiley, Chichester, 1979). Google Scholar  * Antelman, S.M., Caggiula, A.R. _Science_ 195, 646


(1977). Article  ADS  CAS  Google Scholar  * Tassin, J.P. _et al._ _Nature_ 295, 696 (1982). Article  ADS  CAS  Google Scholar  * Yorkston, N.J., Zaki, S.A., Weller, M.P., Gruzelier, J.H.


& Hirsch, S.R. _Acta psychiat. scand._ 63, 13 (1981). Article  CAS  Google Scholar  * Peet, M., Middlemiss, D.An. & Yates, R.A. _Br. J. Psychiat._ 138, 112 (1981). Article  Google


Scholar  * Freedman, R. _et al._ _Acta psychiat. scand._ 65, 35 (1982). Article  CAS  Google Scholar  * Adler, L.E., Bell, J., Kirch, D., Friedrich, E. & Freedman, R. _Am. J. Psychiat._


139, 110 (1982). Article  CAS  Google Scholar  * Langer, S.Z. _Pharmac. Rev._ 102, 337 (1981). Google Scholar  * Holmberg, G. & Gershon, S. _Psychopharmacologia_ 2, 93 (1961). Article 


CAS  Google Scholar  * Feldman, P.E. _J. clin. exp. Psychopath_, 20, 235 (1959). CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Professor of


Biochemical Pharmacology at the Faculty of Medicine of the University of Vienna, A-1090, Borschkeg, 8A, Austria Oleh Hornykiewicz Authors * Oleh Hornykiewicz View author publications You can


also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hornykiewicz, O. Brain catecholamines in


schizophrenia — a good case for noradrenaline. _Nature_ 299, 484–486 (1982). https://doi.org/10.1038/299484a0 Download citation * Issue Date: 07 October 1982 * DOI:


https://doi.org/10.1038/299484a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently


available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative