Characterization of melanin-concentrating hormone in chum salmon pituitaries

Characterization of melanin-concentrating hormone in chum salmon pituitaries

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ABSTRACT Many lower vertebrates exhibit colour change in response to the background. A dual hormonal control of colour change by two antagonistic pituitary melanophorotropic hormones was first postulated in amphibia by Hogben and Slome1. It is well established that the melanotropins α- and β-MSH are responsible for pigment dispersion in the integumentary melanophore of lower vertebrates and that these molecules are derived from a common precursor protein, proopiocortin, by specific processing within the intermediate lobe2. No evidence has been found for an antagonistic hormone in amphibia, although the existence of such a molecule in the pituitary gland of teleost fishes has long been recognized and was termed the melanophore-concentrating hormone by Enami3. Early attempts4,5 to separate the two hormones proved unsuccessful. Recently, Baker and Ball6 re-invoked the dual hormone concept, and it has been suggested7 that a melanin-concentrating hormone (MCH) is synthesized in the hypothalamus of teleosts and stored and released by the neurohyphophysis. We have now isolated a novel peptide from the pituitary of the salmon (_Oncorhynchus keta_) possessing an antagonistic function to MSH, and we describe here its chemical and biological characteristics. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS FROM EXTRAOCULAR PHOTORECEPTION TO PIGMENT MOVEMENT REGULATION: A NEW CONTROL MECHANISM OF THE LANTERNSHARK LUMINESCENCE Article Open access 23 June 2020 DAY LENGTH REGULATES GONADOTROPE PROLIFERATION AND REPRODUCTION VIA AN INTRA-PITUITARY PATHWAY IN THE MODEL VERTEBRATE _ORYZIAS LATIPES_ Article Open access 30 March 2024 MELANOPSIN-MEDIATED OPTICAL ENTRAINMENT REGULATES CIRCADIAN RHYTHMS IN VERTEBRATES Article Open access 18 October 2023 REFERENCES * Hogben, L. & Slome, D. _Proc. R. Soc._ B108, 10–53 (1931). Article  ADS  CAS  Google Scholar  * Eipper, B. A. & Mains, R. E. _Endocr. Rev._ 1, 1–27 (1980). Article  CAS  Google Scholar  * Enami, M. _Science_ 121, 36–37 (1955). Article  ADS  CAS  Google Scholar  * Pickford, G. E. & Atz, J. W. _The Physiology of the Pituitary Gland of Fishes_ (New York Zoological Society, 1957). Google Scholar  * Kent, A. K. _Gen. comp. Endocr._ 1, 409–415 (1961). Article  CAS  Google Scholar  * Baker, B. I. & Ball, J. N. _Gen. comp. Endocr._ 25, 147–152 (1975). Article  CAS  Google Scholar  * Rance, T. A. & Baker, B. I. _Gen. comp. Endocr._ 37, 64–73 (1978). Article  Google Scholar  * Kawauchi, H. & Muramoto, K. _Int. J. Peptide Protein Res._ 14, 373–374 (1979). Article  CAS  Google Scholar  * Kawauchi, H., Adachi, Y. & Tsubokawa, M. _Biochem. biophys. Res. Commun._ 96, 1508–1517 (1980). Article  CAS  Google Scholar  * Kawauchi, H., Adachi, Y. & Ishizuka, B. _Int. J. Peptide Protein Res._ 16, 79–82 (1980). Article  CAS  Google Scholar  * Kawauchi, H., Kawazoe, I., Adachi, Y., Buckley, D. I. & Ramachandran, J. _Gen. comp. Endocr._ (in the press). * Kawauchi, H., Takahashi, A. & Abe, K. _Int. J. Peptide Protein Res._ 18, 223–227 (1981). Article  CAS  Google Scholar  * Kawauchi, H., Tsubokawa, M. & Muramoto, K. _Biochem. biophys. Res. Commun._ 88, 1249–1254 (1979). Article  CAS  Google Scholar  * Kawauchi, H., Tsubokawa, M., Kanezawa, A. & Kitagawa, H. _Biochem. biophys. Res. Commun._ 92, 1278–1288 (1980). Article  CAS  Google Scholar  * Kawauchi, H., Abe, K. & Takahashi, A. _Bull. Japan Soc. Sci. Fish._ 46, 743–747 (1980). Article  CAS  Google Scholar  * Kawauchi, H., Takahashi, A. & Abe, K. _Archs. Biochem. Biophys._ 213, 680–688 (1982). Article  CAS  Google Scholar  * Kawauchi, H. _et al._ _Gen. comp. Endocr._ 49, 446–458 (1983). Article  CAS  Google Scholar  * Imai, K. _Endocr. Japan_ 5, 34–48 (1958). Article  CAS  Google Scholar  * Westerfield, D. B., Pang, P. K. T. & Burns, J. M. _Gen. comp. Endocr._ 42, 494–499 (1980). Article  CAS  Google Scholar  * Muramoto, K., Kawauchi, H. & Tsuzimura, K. _Agric. biol. Chem._ 42, 1559–1563 (1978). CAS  Google Scholar  * Bruton, C. J. & Hartley, B. S. _J. molec. Biol._ 52, 165–178 (1970). Article  CAS  Google Scholar  * Baker, B. I. & Rance, T. A. _Gen. comp. Endocr._ 50, 335–347 (1983). Article  Google Scholar  * Kent, A. K. _Nature_ 183, 544–545 (1959). Article  ADS  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Molecular Endocrinology, School of Fisheries Sciences, Kitasato University, Sanriku, Iwate, 022-01, Japan Hiroshi Kawauchi, Ichiro Kawazoe, Makoto Tsubokawa & Mitsuyo Kishida * School of Biological Sciences, Bath University, Bath, BA2 7AY, UK Bridget I. Baker Authors * Hiroshi Kawauchi View author publications You can also search for this author inPubMed Google Scholar * Ichiro Kawazoe View author publications You can also search for this author inPubMed Google Scholar * Makoto Tsubokawa View author publications You can also search for this author inPubMed Google Scholar * Mitsuyo Kishida View author publications You can also search for this author inPubMed Google Scholar * Bridget I. Baker View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kawauchi, H., Kawazoe, I., Tsubokawa, M. _et al._ Characterization of melanin-concentrating hormone in chum salmon pituitaries. _Nature_ 305, 321–323 (1983). https://doi.org/10.1038/305321a0 Download citation * Received: 25 April 1983 * Accepted: 14 July 1983 * Issue Date: 22 September 1983 * DOI: https://doi.org/10.1038/305321a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT Many lower vertebrates exhibit colour change in response to the background. A dual hormonal control of colour change by two antagonistic pituitary melanophorotropic hormones was


first postulated in amphibia by Hogben and Slome1. It is well established that the melanotropins α- and β-MSH are responsible for pigment dispersion in the integumentary melanophore of lower


vertebrates and that these molecules are derived from a common precursor protein, proopiocortin, by specific processing within the intermediate lobe2. No evidence has been found for an


antagonistic hormone in amphibia, although the existence of such a molecule in the pituitary gland of teleost fishes has long been recognized and was termed the melanophore-concentrating


hormone by Enami3. Early attempts4,5 to separate the two hormones proved unsuccessful. Recently, Baker and Ball6 re-invoked the dual hormone concept, and it has been suggested7 that a


melanin-concentrating hormone (MCH) is synthesized in the hypothalamus of teleosts and stored and released by the neurohyphophysis. We have now isolated a novel peptide from the pituitary of


the salmon (_Oncorhynchus keta_) possessing an antagonistic function to MSH, and we describe here its chemical and biological characteristics. Access through your institution Buy or


subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online


access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which


are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS


FROM EXTRAOCULAR PHOTORECEPTION TO PIGMENT MOVEMENT REGULATION: A NEW CONTROL MECHANISM OF THE LANTERNSHARK LUMINESCENCE Article Open access 23 June 2020 DAY LENGTH REGULATES GONADOTROPE


PROLIFERATION AND REPRODUCTION VIA AN INTRA-PITUITARY PATHWAY IN THE MODEL VERTEBRATE _ORYZIAS LATIPES_ Article Open access 30 March 2024 MELANOPSIN-MEDIATED OPTICAL ENTRAINMENT REGULATES


CIRCADIAN RHYTHMS IN VERTEBRATES Article Open access 18 October 2023 REFERENCES * Hogben, L. & Slome, D. _Proc. R. Soc._ B108, 10–53 (1931). Article  ADS  CAS  Google Scholar  * Eipper,


B. A. & Mains, R. E. _Endocr. Rev._ 1, 1–27 (1980). Article  CAS  Google Scholar  * Enami, M. _Science_ 121, 36–37 (1955). Article  ADS  CAS  Google Scholar  * Pickford, G. E. & Atz,


J. W. _The Physiology of the Pituitary Gland of Fishes_ (New York Zoological Society, 1957). Google Scholar  * Kent, A. K. _Gen. comp. Endocr._ 1, 409–415 (1961). Article  CAS  Google


Scholar  * Baker, B. I. & Ball, J. N. _Gen. comp. Endocr._ 25, 147–152 (1975). Article  CAS  Google Scholar  * Rance, T. A. & Baker, B. I. _Gen. comp. Endocr._ 37, 64–73 (1978).


Article  Google Scholar  * Kawauchi, H. & Muramoto, K. _Int. J. Peptide Protein Res._ 14, 373–374 (1979). Article  CAS  Google Scholar  * Kawauchi, H., Adachi, Y. & Tsubokawa, M.


_Biochem. biophys. Res. Commun._ 96, 1508–1517 (1980). Article  CAS  Google Scholar  * Kawauchi, H., Adachi, Y. & Ishizuka, B. _Int. J. Peptide Protein Res._ 16, 79–82 (1980). Article 


CAS  Google Scholar  * Kawauchi, H., Kawazoe, I., Adachi, Y., Buckley, D. I. & Ramachandran, J. _Gen. comp. Endocr._ (in the press). * Kawauchi, H., Takahashi, A. & Abe, K. _Int. J.


Peptide Protein Res._ 18, 223–227 (1981). Article  CAS  Google Scholar  * Kawauchi, H., Tsubokawa, M. & Muramoto, K. _Biochem. biophys. Res. Commun._ 88, 1249–1254 (1979). Article  CAS 


Google Scholar  * Kawauchi, H., Tsubokawa, M., Kanezawa, A. & Kitagawa, H. _Biochem. biophys. Res. Commun._ 92, 1278–1288 (1980). Article  CAS  Google Scholar  * Kawauchi, H., Abe, K.


& Takahashi, A. _Bull. Japan Soc. Sci. Fish._ 46, 743–747 (1980). Article  CAS  Google Scholar  * Kawauchi, H., Takahashi, A. & Abe, K. _Archs. Biochem. Biophys._ 213, 680–688


(1982). Article  CAS  Google Scholar  * Kawauchi, H. _et al._ _Gen. comp. Endocr._ 49, 446–458 (1983). Article  CAS  Google Scholar  * Imai, K. _Endocr. Japan_ 5, 34–48 (1958). Article  CAS


  Google Scholar  * Westerfield, D. B., Pang, P. K. T. & Burns, J. M. _Gen. comp. Endocr._ 42, 494–499 (1980). Article  CAS  Google Scholar  * Muramoto, K., Kawauchi, H. & Tsuzimura,


K. _Agric. biol. Chem._ 42, 1559–1563 (1978). CAS  Google Scholar  * Bruton, C. J. & Hartley, B. S. _J. molec. Biol._ 52, 165–178 (1970). Article  CAS  Google Scholar  * Baker, B. I.


& Rance, T. A. _Gen. comp. Endocr._ 50, 335–347 (1983). Article  Google Scholar  * Kent, A. K. _Nature_ 183, 544–545 (1959). Article  ADS  CAS  Google Scholar  Download references AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Molecular Endocrinology, School of Fisheries Sciences, Kitasato University, Sanriku, Iwate, 022-01, Japan Hiroshi Kawauchi, Ichiro


Kawazoe, Makoto Tsubokawa & Mitsuyo Kishida * School of Biological Sciences, Bath University, Bath, BA2 7AY, UK Bridget I. Baker Authors * Hiroshi Kawauchi View author publications You


can also search for this author inPubMed Google Scholar * Ichiro Kawazoe View author publications You can also search for this author inPubMed Google Scholar * Makoto Tsubokawa View author


publications You can also search for this author inPubMed Google Scholar * Mitsuyo Kishida View author publications You can also search for this author inPubMed Google Scholar * Bridget I.


Baker View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kawauchi, H.,


Kawazoe, I., Tsubokawa, M. _et al._ Characterization of melanin-concentrating hormone in chum salmon pituitaries. _Nature_ 305, 321–323 (1983). https://doi.org/10.1038/305321a0 Download


citation * Received: 25 April 1983 * Accepted: 14 July 1983 * Issue Date: 22 September 1983 * DOI: https://doi.org/10.1038/305321a0 SHARE THIS ARTICLE Anyone you share the following link


with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt


content-sharing initiative