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ABSTRACT An essential property of the immune response is its ability to distinguish between self and non-self and to generate enormous diversity in antibody and T-cell immune responses.
Although the genetic and molecular mechanisms responsible for antibody diversity have now largely been elucidated, the structure of the T-cell receptor and the diversification of the
receptor repertoire have only recently become amenable to study. One approach has involved immunochemical studies of the protein precipitated by monoclonal antibodies which react
specifically with the immunizing T-cell clones1–3. Another approach has been to clone and sequence a human4 or a murine5 T-cell specific message that may specify part of the T-cell receptor.
We present here results of Southern blot analysis of non-T, immature T, and mature T-cell genomic DNA, and provide evidence that rearrangements of the _YT35_ sequences do occur in the DNA
of thymic leukaemia T cells. This suggests that _YT35_ codes for at least part of the T-cell receptor and that rearrangements occur at this early stage of thymic ontogeny. Furthermore, DNA
rearrangements are present in lymphocytes with phenotypic and functional characteristics of helper, killer, or suppressor T cells. We conclude that the three subpopulations of T cells
operate via receptor molecules encoded by the same gene family. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS
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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS FEATURES OF REPERTOIRE DIVERSITY AND GENE EXPRESSION IN HUMAN CYTOTOXIC T CELLS
FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION Article Open access 11 October 2021 INTEGRATING T CELL RECEPTOR SEQUENCES AND TRANSCRIPTIONAL PROFILES BY CLONOTYPE NEIGHBOR GRAPH
ANALYSIS (CONGA) Article 23 August 2021 DUAL T-CELL CONSTANT Β CHAIN (TRBC)1 AND TRBC2 STAINING FOR THE IDENTIFICATION OF T-CELL NEOPLASMS BY FLOW CYTOMETRY Article Open access 29 February
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Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10031, USA AUTHORS AND AFFILIATIONS * The Ontario Cancer Institute and Department of Medical
Biophysics, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, Canada, M4X 1K9 Barry Toyonaga, Yusuke Yanagi, Nicole Suciu-Foca, Mark Minden & Tak W. Mak Authors * Barry
Toyonaga View author publications You can also search for this author inPubMed Google Scholar * Yusuke Yanagi View author publications You can also search for this author inPubMed Google
Scholar * Nicole Suciu-Foca View author publications You can also search for this author inPubMed Google Scholar * Mark Minden View author publications You can also search for this author
inPubMed Google Scholar * Tak W. Mak View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE
CITE THIS ARTICLE Toyonaga, B., Yanagi, Y., Suciu-Foca, N. _et al._ Rearrangements of T-cell receptor gene _YT35_ in human DNA from thymic leukaemia T-cell lines and functional T-cell
clones. _Nature_ 311, 385–387 (1984). https://doi.org/10.1038/311385a0 Download citation * Received: 25 April 1984 * Accepted: 23 July 1984 * Issue Date: 27 September 1984 * DOI:
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