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Access through your institution Buy or subscribe Classical transplantation studies established that the CM was necessary and sufficient for early hepatogenesis. Equipped with a new,
ST-specific marker, Rossi _et al_. realized that ST cells are frequently present in CM explants because of the tight association between these tissues. This raised the possibility that they
too could function in early hepatogenesis. To investigate further, the authors analysed the ST mesenchyme in a _Bmp4_ _LacZ_ mouse in which _LacZ_ disrupts the _Bmp4_. Expression of _LacZ_
was strong in the ST and early hepatogenesis was severely retarded in _Bmp4__LacZ_ homozygous mice. A more severe liver phenotype only became apparent when exogenous noggin — a general BMP
antagonist — was added, indicating that other members of the BMP family, also expressed in the ST, are required for hepatogenesis and might compensate for the loss of Bmp4 in the
_Bmp4__LacZ_ mice. They also noticed that the expression of albumin — an early liver-specific gene — was absent when the BMPs were blocked by noggin and that the FGF signal from the CM could
not substitute for the BMP-induced albumin expression. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to
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support ORIGINAL RESEARCH PAPER * Rossi, J. M. et al. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from
the endoderm. _Genes Dev._ 15, 1998–2009 (2001) Article CAS Google Scholar Download references Authors * Magdalena Skipper View author publications You can also search for this author
inPubMed Google Scholar RELATED LINKS RELATED LINKS WEB SITE Ken Zaret's lab RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Skipper, M. BMP
de-livers. _Nat Rev Genet_ 2, 654 (2001). https://doi.org/10.1038/35088543 Download citation * Issue Date: 01 September 2001 * DOI: https://doi.org/10.1038/35088543 SHARE THIS ARTICLE Anyone
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