ABSTRACT CYCLIC AMP acts as a second messenger in the modulation of several ion channels1–9 that are typically controlled by a phosphorylation process10. In cardiac pacemaker cells,

adrenaline and acetylcholine regulate the hyperpolarization-activated current (_i_f), but in opposite ways; this current is involved in the generation and modulation of pacemaker activity11.

These actions are mediated by cAMP and underlie control of spontaneous rate by neurotransmitters12–17. Whether the cAMP modulation of _i_f is mediated by channel phosphorylation is,

however, still unknown. Here we investigate the action of cAMP on _i_f in excised patches of cardiac pacemaker cells and find that cAMP activates _i_f by a mechanism independent of

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A HIGH AFFINITY SWITCH FOR CAMP IN THE HCN PACEMAKER CHANNELS Article Open access 29 January 2024 ELECTROMECHANICAL COUPLING MECHANISM FOR ACTIVATION AND INACTIVATION OF AN HCN CHANNEL

Article Open access 14 May 2021 CAMP-DEPENDENT REGULATION OF HCN4 CONTROLS THE TONIC ENTRAINMENT PROCESS IN SINOATRIAL NODE PACEMAKER CELLS Article Open access 03 November 2020 REFERENCES *

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Universitá di Milano, via Celoria 26, 20133, Milano, Italy Dario DiFrancesco & Paolo Tortora Authors * Dario DiFrancesco View author publications You can also search for this author

inPubMed Google Scholar * Paolo Tortora View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE DiFrancesco, D., Tortora, P. Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. _Nature_ 351, 145–147 (1991).

https://doi.org/10.1038/351145a0 Download citation * Received: 26 October 1990 * Accepted: 04 March 1991 * Issue Date: 09 May 1991 * DOI: https://doi.org/10.1038/351145a0 SHARE THIS ARTICLE

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